{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:45:45Z","timestamp":1791362745529,"version":"4.3.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":6793,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[2001]]},"DOI":"10.1254\/jjp.87.195","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:44:18Z","timestamp":1030380258000},"page":"195-201","source":"Crossref","is-referenced-by-count":119,"title":["Deterioration of Spatial Learning Performances in Lipopolysaccharide-Treated Mice"],"prefix":"10.1016","volume":"87","author":[{"given":"Ken","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikegaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.87.195_bib1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0006-8993(92)90779-9","article-title":"Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysac-charide in rats","volume":"573","author":"Bluth\u2019e","year":"1992","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib2","first-page":"63","article-title":"Endotoxin-induced behavioral changes of mice in the multicompartment chamber are distinct from those of interleukin-1","volume":"10","author":"Dunn","year":"1992","journal-title":"Neurosci Res Commun"},{"key":"10.1254\/jjp.87.195_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physrev.1991.71.1.93","article-title":"Fever: role of pyrogens and cryogens","volume":"71","author":"Kluger","year":"1991","journal-title":"Physiol Rev"},{"key":"10.1254\/jjp.87.195_bib4","first-page":"R125","article-title":"Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice","volume":"266","author":"Kozak","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1254\/jjp.87.195_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1615\/CritRevImmunol.v14.i3-4.70","article-title":"Microbial products and cytokines in sleep and fever regulation","volume":"14","author":"Krueger","year":"1994","journal-title":"Crit Rev Immunol"},{"key":"10.1254\/jjp.87.195_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0006-8993(94)91908-9","article-title":"Behavioral effects of lipopolysaccharide in rats: involvement of endogenous opioids","volume":"648","author":"Yirmiya","year":"1994","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(95)01415-2","article-title":"Endotoxin produces a depressive like episode in rats","volume":"711","author":"Yirmiya","year":"1996","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0006-8993(97)00927-X","article-title":"Different receptor mechanisms mediate the effects of endotoxin and interleukin-1 on female sexual behavior","volume":"773","author":"Avistur","year":"1997","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib9","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1523\/JNEUROSCI.18-06-02239.1998","article-title":"Exposure to acute stress induces brain interleukin-1beta protein in the rat","volume":"18","author":"Nguyen","year":"1998","journal-title":"J Neurosci"},{"key":"10.1254\/jjp.87.195_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0169-328X(94)90197-X","article-title":"Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice","volume":"27","author":"Lay\u2019e","year":"1994","journal-title":"Mol Brain Res"},{"key":"10.1254\/jjp.87.195_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1749-6632.1998.tb09558.x","article-title":"Brain neurotransmission during peripheral inflammation","volume":"840","author":"Linthorst","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"10.1254\/jjp.87.195_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1254\/jjp.87.195_bib13","first-page":"964","article-title":"Endotoxin-induced activation of cerebral catechola-mine and serotonin metabolism: Comparison with interleukin-1","volume":"261","author":"Dunn","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.87.195_bib14","first-page":"195","article-title":"Neuroimmunomodulation via limbic structures - The neuroanatomy of psychoimmunology","volume":"51","author":"Haas","year":"1997","journal-title":"Prog Brain Res"},{"key":"10.1254\/jjp.87.195_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jnr.490400316","article-title":"Endotoxin administration stimulates cerebral catecholamine release in freely moving rats as assessed by microdialysis","volume":"40","author":"Lavicky","year":"1995","journal-title":"J Neurosci Res"},{"key":"10.1254\/jjp.87.195_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0006-8993(99)01206-8","article-title":"Lipopolysaccharide-induced changes in monoamines in specific areas of the brain: blockade by interleukin-1 receptor antagonist","volume":"824","author":"MohanKumar","year":"1999","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0306-4522(95)00604-4","article-title":"Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway","volume":"72","author":"Linthorst","year":"1996","journal-title":"Neuroscience"},{"key":"10.1254\/jjp.87.195_bib18","first-page":"460","article-title":"The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice","volume":"276","author":"Yamada","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.87.195_bib19","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1248\/bpb.18.1513","article-title":"Beneficial effects of Biota, a traditional Chinese herbal medicine, on learning impairment induced by basal forebrain-lesion in mice","volume":"18","author":"Nishiyama","year":"1995","journal-title":"Biol Pharm Bull"},{"key":"10.1254\/jjp.87.195_bib20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1254\/jjp.87.195_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0006-8993(93)90468-3","article-title":"Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning","volume":"613","author":"Oitzl","year":"1993","journal-title":"Brain Res"},{"key":"10.1254\/jjp.87.195_bib22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/brbi.1998.0524","article-title":"Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning","volume":"12","author":"Pugh","year":"1998","journal-title":"Brain Behav Immun"},{"key":"10.1254\/jjp.87.195_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0028-3932(79)90042-3","article-title":"Spatial memory and hippocampal function","volume":"17","author":"Olton","year":"1979","journal-title":"Neuropsychologia"},{"key":"10.1254\/jjp.87.195_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0197-4580(99)00028-7","article-title":"The effects of a novel NSAID in chronic neuroinflammation are age dependent","volume":"20","author":"Hauss-Wegrzyniak","year":"1999","journal-title":"Neurobiol Aging"},{"key":"10.1254\/jjp.87.195_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0306-4522(98)00237-1","article-title":"Brain dysfunction associated with an induction of nitric oxide synthase following an intra-cerebral injection of lipopolysaccharide in rats","volume":"88","author":"Yamada","year":"1999","journal-title":"Neuroscience"},{"key":"10.1254\/jjp.87.195_bib26","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1073\/pnas.93.10.4750","article-title":"Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation","volume":"93","author":"Kim","year":"1996","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819302653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819302653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:08:36Z","timestamp":1605636516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819302653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001]]}},"alternative-id":["S0021519819302653"],"URL":"https:\/\/doi.org\/10.1254\/jjp.87.195","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}