{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:50:22Z","timestamp":1777132222368,"version":"3.51.4"},"reference-count":34,"publisher":"Japanese Pharmacological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1254\/jphs.08222fp","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T05:56:19Z","timestamp":1229925379000},"page":"480-486","source":"Crossref","is-referenced-by-count":42,"title":["Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate\u2013Sensitized Rats"],"prefix":"10.1254","volume":"108","author":[{"given":"Hiroyuki","family":"Mizuguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyo","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Umehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakana","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Nathan RA, Meltzer EO, Selner JC, Storms W. Prevalence of allergic rhinitis in the United States. J Allergy Clin Immunol. 1997;99:S808&ndash;S814.","DOI":"10.1016\/S0091-6749(97)80040-1"},{"key":"2","unstructured":"2 Baba K, Konno A, Takenaka H, editors. Practical guideline for the management of allergic rhinitis in Japan. Tokyo: Life Science; 2005."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Juniper EF, Kline PA, Hargreave FE, Dolovich J. Comparison of beclomethasone, dipropionate aqueous nasal spray, astemizole, and the combination in the prophylactic treatment of ragweed pollen-induced rhinoconjunctivitis. J Allergy Clin Immunol. 1989;83:627&ndash;633.","DOI":"10.1016\/0091-6749(89)90075-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01026.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Kurowski M, Kuna O, Gorski P. Montelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation. Allergy. 2004;59:280&ndash;288.","DOI":"10.1046\/j.1398-9995.2003.00416.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Peters JM, Wegman DH. Epidemiology of toluene diisocyanate (TDI)-induced respiratory disease. Environ Health Perspect. 1975;11:97&ndash;100.","DOI":"10.1289\/ehp.751197"},{"key":"7","unstructured":"7 Mapp CE, Boschetto P, Zocca E, Milani GF, Pivirotto F, Tegazzin V, et al. Pathogenesis of late asthmatic reactions induced by exposure to isocyanates. Bull Eur Physiopathol Respir. 1987;23:583&ndash;586."},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137463"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90692-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Takeda N, Morita M, Hasegawa S, Horii A, Kubo T, Matsunaga T. Neuropharmacology of motion sickness and emesis. A review. Acta Otolarygol Suppl. 1993;501:10&ndash;15.","DOI":"10.3109\/00016489309126205"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Abe Y, Ogina S, Irifune M, Imamura I, Liu YQ, Fukui H, et al. Histamine content, synthesis and degradation in nasal mucosa and lung of guinea-pigs treated with toluene diisocyanate (TDI). Clin Exp Allergy. 1993;23:512&ndash;517.","DOI":"10.1111\/j.1365-2222.1993.tb03239.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410022525"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-003-0304-7"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.279"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Holgate, ST. The 1992 Cournand Lecture. Asthma: past, present and future. Eur Respir J. 1993;6:1507&ndash;1520.","DOI":"10.1183\/09031936.93.06101507"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.701"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.1.123"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.3791276.x"},{"issue":"5","key":"19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1165\/ajrcmb.18.5.2909","volume":"18","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1044-1549","issn-type":"print"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01881-5"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Delneste Y, Lassalle P, Jeannin P, Joseph M, Tonnel AB, Gosset P. Histamine induces IL-6 production by human endothelial cells. Clin Exp Immnol. 1994;98:344&ndash;349.","DOI":"10.1111\/j.1365-2249.1994.tb06148.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Tanaka K, Okamoto Y, Nagata Y, Nishimura F, Takeoka A, Hanada S, et al. A nasal allergy model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate. Int Arch Allergy Appl Immunol. 1988;85:392&ndash;397.","DOI":"10.1159\/000234540"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80223-4"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Bachert C. Histamine-a major role in allergy? Clin Exp Allergy. 1998;28 Suppl 6:15&ndash;19.","DOI":"10.1046\/j.1365-2222.1998.0280s6015.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Shimada H. The factor of hypersensitivity of human nasal mucosa: receptor binding assay of H1Rs. J Jpn Rhinol Soc. 1990;29:225&ndash;233.","DOI":"10.7248\/jjrhi1982.29.2_225"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Iriyoshi N, Takeuchi K, Yuta A, Ukai K, Sakakura Y. Increased expression of H1R mRNA in allergic rhinitis. Clin Exp Allergy. 1996;26:379&ndash;385.","DOI":"10.1111\/j.1365-2222.1996.tb00553.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Dinh QT, Cryer A, Dinh S, Peiser C, Wu S, Springer J, et al. Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis. Clin Exp Allergy. 2005;35:1443&ndash;1448.","DOI":"10.1111\/j.1365-2222.2005.02359.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Terada N, Hamano N, Maesako KI, Hiruma K, Hohki G, Suzuki K, et al. Diesel exhaust particulates up-regulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells. Clin Exp Allergy. 1999;29:52&ndash;59.","DOI":"10.1046\/j.1365-2222.1999.00406.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8080"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, et al. IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. J Immunol. 1999;162:5455&ndash;5465.","DOI":"10.4049\/jimmunol.162.9.5455"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Igaz P, Novak I, Lazar E, Horvath B, Heninger E, Faauls A. Bidirectional communication between histamine and cytokines. Inflamm Res. 2001;123&ndash;128.","DOI":"10.1007\/s000110050735"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70256-8"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111236"},{"issue":"6","key":"34","first-page":"1253","volume":"40","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/1039-9712","issn-type":"print"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:08:29Z","timestamp":1684811309000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/108\/4\/108_08222FP\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.08222fp","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}