{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:22:42Z","timestamp":1789564962036,"version":"build-2803163510"},"reference-count":56,"publisher":"Japanese Pharmacological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1254\/jphs.09r23fm","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:03:26Z","timestamp":1274659406000},"page":"103-109","source":"Crossref","is-referenced-by-count":75,"title":["Roles of Oral Bacteria in Cardiovascular Diseases \u2014 From Molecular Mechanisms to Clinical Cases: Implication of Periodontal Diseases in Development of Systemic Diseases"],"prefix":"10.1254","volume":"113","author":[{"given":"Hiroaki","family":"Inaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90263-T"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Hujoel PP, Drangsholt M, Spiekerman C, Derouen TA. Examining the link between coronary heart disease and the elimination of chronic dental infections. J Am Dent Assoc. 2001;132:883&ndash;889.","DOI":"10.14219\/jada.archive.2001.0300"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.107"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Ishihara K, Nabuchi A, Ito R, Miyachi K, Kuramitsu HK, Okuda K. Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque corrected and in dental plaque samples. J Clin Microbiol. 2004;42:1313&ndash;1315.","DOI":"10.1128\/JCM.42.3.1313-1315.2004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.03.016"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, et al. Detection of oral bacteria in cardiovascular specimens. Oral Microbiol Immunol. 2009;24:64&ndash;68.","DOI":"10.1111\/j.1399-302X.2008.00479.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801&ndash;809.","DOI":"10.1038\/362801a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Kuramitsu HK, Kang IC, Qi M. Interactions of <I>Porphyromonas gingivalis<\/I> with host cells: implications for cardiovascular diseases. J Periodontol. 2003;74:85&ndash;89.","DOI":"10.1902\/jop.2003.74.1.85"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Vettore MV, Leal M, Le&atilde;o AT, da Silva AM, Lamarca GA, Sheiham A. The relationship between periodontitis and preterm low birthweight. J Dent Res. 2008;87:73&ndash;78.","DOI":"10.1177\/154405910808700113"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Wimmer G, Pihlstrom BL. A critical assessment of adverse pregnancy outcome and periodontal disease. J Clin Periodontol. 2008;35:380&ndash;397.","DOI":"10.1111\/j.1600-051X.2008.01284.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Leon R, Silva N, Ovalle A, Chaparro A, Ahumada A, Gajardo M, et al. Detection of <I>Porphyromonas gingivalis<\/I> in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol. 2007;78:1249&ndash;1255.","DOI":"10.1902\/jop.2007.060368"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Barak S, Oettinger-Barak O, Machtei EE, Sprecher H, Ohel G. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol. 2007;78:670&ndash;676.","DOI":"10.1902\/jop.2007.060362"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Katz J, Chegini N, Shiverick KT, Lamont RJ. Localization of <I>P. gingivalis<\/I> in preterm delivery placenta. J Dent Res. 2009;88:575&ndash;578.","DOI":"10.1177\/0022034509338032"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Inaba H, Kuboniwa M, Bainbridge B, Yilmaz O, Katz J, Shiverick KT, et al. <I>Porphyromonas gingivalis<\/I> invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis. Cell Microbiol. 2009;11:1517&ndash;1532.","DOI":"10.1111\/j.1462-5822.2009.01344.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Takeda M, Ojima M, Yoshioka H, Inaba H, Kogo M, Shizukuishi S, et al. Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol. 2006;77:15&ndash;20.","DOI":"10.1902\/jop.2006.77.1.15"},{"key":"16","unstructured":"16 Silvestre FJ, Miralles L, Llambes F, Bautista D, Sol&aacute;-Izquierdo E, Hern&aacute;ndez-Mijares A. Type 1 diabetes mellitus and periodontal disease: relationship to different clinical variables. Med Oral Patol Oral Cir Bucal. 2009;14:E175&ndash;E179."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Tervonen T, Lamminsalo S, Hiltunen L, Raunio T, Knuuttila M. Resolution of periodontal inflammation does not guarantee improved glycemic control in type 1 diabetic subjects. J Clin Periodontol. 2009;36:51&ndash;57.","DOI":"10.1111\/j.1600-051X.2008.01343.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Makiura N, Ojima M, Kou Y, Furuta N, Okahashi N, Shizukuishi S, et al. Relationship of <I>Porphyromonas gingivalis<\/I> with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiol Immunol. 2008;23:348&ndash;351.","DOI":"10.1111\/j.1399-302X.2007.00426.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Leuckfeld I, Obregon-Whittle MV, Lund MB, Geiran O, Bj&oslash;rtuft &Oslash;, Olsen I. Severe chronic obstructive pulmonary disease: association with marginal bone loss in periodontitis. Respir Med. 2008;102:488&ndash;494.","DOI":"10.1016\/j.rmed.2007.12.001"},{"key":"20","unstructured":"20 Reddy MS. Oral osteoporosis: is there an association between periodontitis and osteoporosis? Compend Contin Educ Dent. 2002;23:21&ndash;28."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Groen JJ, Menczel J, Shapiro S. Chronic destructive periodontal disease in patients with presenile osteoporosis. J Periodontol. 1968;39:19&ndash;23.","DOI":"10.1902\/jop.1968.39.1.19"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01798.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Holt SC, Ebersole JL. <I>Porphyromonas gingivalis<\/I>, <I>Treponema denticola<\/I>, and <I>Tannerella forsythia<\/I>: the &#8220;red complex&#8221;, a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000. 2005;38:72&ndash;122.","DOI":"10.1111\/j.1600-0757.2005.00113.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Milward MR, Chapple IL, Wright HJ, Millard JL, Mattews JB, Cooper PR. Differential activation of NF-<I>&kappa;<\/I>B and gene expression in oral epithelial cells by periodontal pathogens. Clin Exp Immunol. 2007;148:307&ndash;324.","DOI":"10.1111\/j.1365-2249.2007.03342.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00011.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Kinane DF, Riggio MP, Walker KF, MacKenzie D, Shearer B. Bacteraemia following periodontal procedures. J Clin Periodontol. 2005;32:708&ndash;713.","DOI":"10.1111\/j.1600-051X.2005.00741.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Matthews JB, Wright HJ, Roberts A, Ling-Mountford N, Cooper PR, Chapple IL. Neutrophil hyper-responsiveness in periodontitis. J Dent Res. 2007;86:718&ndash;722.","DOI":"10.1177\/154405910708600806"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Loos BG. Systemic markers of inflammation in periodontitis. J Periodontol. 2005;76:2106&ndash;2115.","DOI":"10.1902\/jop.2005.76.11-S.2106"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Chapple IL, Brock GR, Milward MR, Ling N, Matthews JB. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol. 2007;34:103&ndash;110.","DOI":"10.1111\/j.1600-051X.2006.01029.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Mercanoglu F, Oflaz H, Oz O, G&ouml;kbuget AY, Genchellac H, Sezer M, et al. Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy. J Periodontol. 2004;75:1694&ndash;1700.","DOI":"10.1902\/jop.2004.75.12.1694"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Seymour GJ, Ford PJ, Cullinan MP, Leishman S, West MJ, Yamazaki K. Infection or inflammation: the link between periodontal and cardiovascular diseases. Future Cardiol. 2009;5:5&ndash;9.","DOI":"10.2217\/14796678.5.1.5"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0060256"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, et al. The american journal of cardiology and journal of periodontology Editors&rsquo; consensus: periodontitis and atherosclerotic cardiovascular disease. Am J Cardiol. 2009;104:59&ndash;68.","DOI":"10.1016\/j.amjcard.2009.05.002"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, et al. The aJournal of cardiology and journal of periodontology editors&rsquo; consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol. 2009;80:1021&ndash;1032.","DOI":"10.1902\/jop.2009.097001"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kes&auml;niemi YA, Syrj&auml;l&auml; SL, et al. Association between dental health and acute myocardial infarction. BMJ. 1989;298:1579&ndash;1580.","DOI":"10.1136\/bmj.298.6687.1580"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1161\/hc0702.104178"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000082462.26258.FE"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129769.17895.F0"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.11.036"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Hokamura K, Inaba H, Nakano K, Nomura R, Yoshioka H, Taniguchi K, et al. Molecular analysis of aortic intimal hyperplasia caused by <I>Porphyromonas gingivalis<\/I> infection in mice with endothelial damage. J Periodontal Res. 2010;45:337&ndash;344.","DOI":"10.1111\/j.1600-0765.2009.01242.x"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09R26FM"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09R22FM"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44 Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75&ndash;84.","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Boggess KA, Madianos PN, Preisser JS, Moise KJ Jr, Offenbacher S. Chronic maternal and fetal <I>Porphyromonas gingivalis <\/I>exposure during pregnancy in rabbits. Am J Obstet Gynecol. 2005;192:554&ndash;557.","DOI":"10.1016\/j.ajog.2004.09.001"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 B&eacute;langer M, Reyes L, von Deneen K, Reinhard MK, Progulske-Fox A, Brown, MB. Colonization of maternal and fetal tissues by <I>Porphyromonas gingivalis <\/I>is strain-dependent in a rodent animal model. Am J Obstet Gynecol. 2008;199:e1&ndash;e7.","DOI":"10.1016\/j.ajog.2007.11.067"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47 Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care. 2007;27:1047&ndash;1053.","DOI":"10.2337\/diacare.27.5.1047"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.99"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49 Grossi SG. Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research. Ann Periodontol. 2001;6:138&ndash;145.","DOI":"10.1902\/annals.2001.6.1.138"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50 Janket SJ, Wightman A, Baird AE, Van Dyke TE, Jones JA. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J Dent Res. 2005;84:1154&ndash;1159.","DOI":"10.1177\/154405910508401212"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00719.x"},{"key":"52","unstructured":"52 Amar S, Han X. The impact of periodontal infection on systemic diseases. Med Sci Monit. 2003;9:RA291&ndash;RA299."},{"key":"53","doi-asserted-by":"crossref","unstructured":"53 Finegold SM, Strong CA, McTeague M, Marina M. The importance of black-pigmented gram negative anaerobes in human infections. FEMS Immunol Med Microbiol. 1993;6:77&ndash;82.","DOI":"10.1111\/j.1574-695X.1993.tb00306.x"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54 Hajishengallis G, Wang M, Bagby GJ, Nelson S. Importance of TLR2 in early innate immune response to acute pulmonary infection with <I>Porphyromonas gingivalis<\/I> in mice. J Immunol. 2008;181:4141&ndash;4149.","DOI":"10.4049\/jimmunol.181.6.4141"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55 Recker R, Lappe J, Davies KM, Heaney R. Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. J Bone Miner Res. 2004;19:1628&ndash;1633.","DOI":"10.1359\/JBMR.040710"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56 Orrico SR, Giro G, Gon&ccedil;alves D, Takayama L, Pereira RM. Influence of the period after ovariectomy on femoral and mandibular bone density and on induced periodontal disease. J Periodontol. 2007;78:164&ndash;169.","DOI":"10.1902\/jop.2007.060136"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T11:07:09Z","timestamp":1621422429000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/113\/2\/113_09R23FM\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.09r23fm","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}