{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:22:54Z","timestamp":1790853774656,"version":"4.1.0"},"reference-count":43,"publisher":"Japanese Pharmacological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1254\/jphs.09r24fm","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T04:03:26Z","timestamp":1274673806000},"page":"120-125","source":"Crossref","is-referenced-by-count":69,"title":["Roles of Oral Bacteria in Cardiovascular Diseases \u2014 From Molecular Mechanisms to Clinical Cases: Cell-Surface Structures of Novel Serotype k Streptococcus mutans Strains and Their Correlation to Virulence"],"prefix":"10.1254","volume":"113","author":[{"given":"Kazuhiko","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ooshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Hamada S, Slade HD. Biology, immunology, and cariogenicity of Streptococcus mutans.<\/I> Microbiol Rev. 1980;44:331–384.","DOI":"10.1128\/MMBR.44.2.331-384.1980"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.233.4759.29"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Nakano K, Ooshima T. Serotype classification of Streptococcus mutans<\/I> and its detection outside the oral cavity. Future Microbiol. 2009;4:891–902.","DOI":"10.2217\/fmb.09.64"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/jb.179.4.1126-1134.1997","volume":"179","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"issue":"13","key":"5","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1128\/jb.179.13.4411-4414.1997","volume":"179","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Yamashita Y, Tsukioka Y, Nakano Y, Tomihisa K, Oho T, Koga T. Biological functions of UDP-glucose synthesis in Streptococcus mutans<\/I>. Microbiology. 1998;144:1235–1245.","DOI":"10.1099\/00221287-144-5-1235"},{"issue":"21","key":"7","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/JB.180.21.5803-5807.1998","volume":"180","author":"YAMASHITA Y","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T. Expression and characterization of streptococcal rgp<\/I> genes required for rhamnan synthesis in Escherichia coli<\/I>. Infect Immun. 2002;70:2891–2898.","DOI":"10.1128\/IAI.70.6.2891-2898.2002"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Kuramitsu HK. Virulence factors of mutans streptococci: role of molecular genetics. Crit Rev Oral Biol Med. 1993;4:159–176.","DOI":"10.1177\/10454411930040020201"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Ooshima T, Matsumura M, Hoshino T, Kawabata S, Sobue S, Fujiwara T. Contributions of three glycosyltransferases to sucrose-dependent adherence of Streptococcus mutans<\/I>. J Dent Res. 2001;80:1672–1677.","DOI":"10.1177\/00220345010800071401"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Koga T, Okahashi N, Takahashi I, Kanamoto T, Asakawa H, Iwaki M. Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans<\/I> serotype c<\/I>. Infect Immun. 1990;58:289–296.","DOI":"10.1128\/IAI.58.2.289-296.1990"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Banas JA, Vickerman MM. Glucan-binding proteins of the oral streptococci. Crit Rev Oral Biol Med. 2003;14:89–99.","DOI":"10.1177\/154411130301400203"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Sato Y, Okamoto K, Kagami A, Yamamoto Y, Igarashi T, Kizaki H. Streptococcus mutans<\/I> strains harboring collagen-binding adhesin. J Dent Res. 2004;83:534–539.","DOI":"10.1177\/154405910408300705"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Nomura R, Nakano K, Taniguchi N, Lapirattanakul J, Nemoto H, Grönroos L, et al. Molecular and clinical analyses of the gene encoding the collagen-binding adhesin of Streptococcus mutans<\/I>. J Med Microbiol. 2009;58:469–475.","DOI":"10.1099\/jmm.0.007559-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Fujiwara T, Nakano K, Kawaguchi M, Ooshima T, Sobue S, Kawabata S, et al. Biochemical and genetic characterization of serologically untypable Streptococcus mutans<\/I> strains isolated from patients with bacteremia. Eur J Oral Sci. 2001;109:330–334.","DOI":"10.1034\/j.1600-0722.2001.00119.x"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jdsr.2007.09.001","volume":"44","author":"NAKANO KAZUHIKO","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1882-7616","issn-type":"print"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Nakano K, Nomura R, Nakagawa I, Hamada S, Ooshima T. Demonstration of Streptococcus mutans<\/I> with a cell wall polysaccharide specific to a new serotype, k<\/I>, in the human oral cavity. J Clin Microbiol. 2004;42:198–202.","DOI":"10.1128\/JCM.42.1.198-202.2004"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Nakano K, Nomura R, Shimizu N, Nakagawa I, Hamada S, Ooshima T. Development of a PCR method for rapid identification of new Streptococcus mutans<\/I> serotype k <\/I>strains. J Clin Microbiol. 2004;42:4925–4930.","DOI":"10.1128\/JCM.42.11.4925-4930.2004"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Waterhouse JC, Russell RR. Dispensable genes and foreign DNA in Streptococcus mutans<\/I>. Microbiology. 2006;152:1777–1788.","DOI":"10.1099\/mic.0.28647-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Nakano K, Lapirattanakul J, Nomura R, Nemoto H, Alaluusua S, Grönroos L, et al. Streptococcus mutans<\/I> clonal variation revealed by multilocus sequence typing. J Clin Microbiol. 2007;45:2616–2625.","DOI":"10.1128\/JCM.02343-06"},{"key":"21","unstructured":"21 Linossier AG, Valenzuela CY, Toledo H. Differences of the oral colonization by Streptococcus of the mutans group in children and adolescents with Down syndrome, mental retardation and normal controls. Med Oral Patol Oral Cir Bucal. 2008;13:E536–E539."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Lapirattanakul J, Nakano K, Nomura R, Nemoto H, Kojima A, Senawongse P, et al. Detection of serotype k Streptococcus mutans<\/I> in Thai subjects. Oral Microbiol Immunol. 2009;24:431–433.","DOI":"10.1111\/j.1399-302X.2009.00530.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Nomura R, Nakano K, Ooshima T. Molecular analysis of the genes involved in the biosynthesis of serotype specific polysaccharide in the novel serotype k <\/I>strains of Streptococcus mutans<\/I>. Oral Microbiol Immunol. 2005;20:303–309.","DOI":"10.1111\/j.1399-302X.2005.00231.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Nakano K, Nomura R, Nemoto H, Lapirattanakul J, Taniguchi N, Grönroos L, et al. Protein antigen in serotype k Streptococcus mutans<\/I> clinical isolates. J Dent Res. 2008;87:964–968.","DOI":"10.1177\/154405910808701001"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Nakano K, Nomura R, Taniguchi N, Lapirattanakul J, Kojima A, Naka S, et al. Molecular characterization of Streptococcus mutans<\/I> strains containing the cnm<\/I> gene encoding a collagen-binding adhesin. Arch Oral Biol. 2010;55:34–39.","DOI":"10.1016\/j.archoralbio.2009.11.008"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Nakano K, Matsumura M, Kawaguchi M, Fujiwara T, Sobue S, Nakagawa I, et al. Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans<\/I>: analysis of strains isolated from human blood. J Dent Res. 2002;81:376–379.","DOI":"10.1177\/0810376"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Nomura R, Nakano K, Ooshima T. Contribution of glucan-binding protein C of Streptococcus mutans<\/I> to bacteremia occurrence. Arch Oral Biol. 2004;49:783–788.","DOI":"10.1016\/j.archoralbio.2004.04.001"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Nakano K, Tsuji M, Nishimura K, Nomura R, Ooshima T. Contribution of cell surface protein antigen PAc of Streptococcus mutans<\/I> to bacteremia. Microbes Infect. 2006;8:114–121.","DOI":"10.1016\/j.micinf.2005.06.005"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(00)00191-9"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Abranches J, Zeng L, Bélanger M, Rodrigues PH, Simpson- Haidaris PJ, Akin D, et al. Invasion of human coronary artery endothelial cells by Streptococcus mutans<\/I> OMZ175. Oral Microbiol Immunol. 2009;24:141–145.","DOI":"10.1111\/j.1399-302X.2008.00487.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Nakano K, Inaba H, Nomura R, Nemoto H, Takeda M, Yoshioka H, et al. Detection of cariogenic Streptococcus mutans<\/I> in extirpated heart valve and atheromatous plaque specimens. J Clin Microbiol. 2006;44:3313–3317.","DOI":"10.1128\/JCM.00377-06"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, et al. Detection of oral bacteria in cardiovascular specimens. Oral Microbiol Immunol. 2009;24:64–68.","DOI":"10.1111\/j.1399-302X.2008.00479.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Nakano K, Nemoto H, Nomura R, Homma H, Yoshioka H, Shudo Y, et al. Serotype distribution of Streptococcus mutans<\/I> a pathogen of dental caries in cardiovascular specimens from Japanese patients. J Med Microbiol. 2007;56:551–556.","DOI":"10.1099\/jmm.0.47051-0"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.11.036"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Hokamura K, Inaba H, Nakano K, Nomura R, Yoshioka H, Taniguchi K, et al. Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis<\/I> infection in mice with endothelial damage. J Periodontal Res. 2010;45:337–344.","DOI":"10.1111\/j.1600-0765.2009.01242.x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01210.x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02390-2"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Chia JS, Lin YL, Lien HT, Chen JY. Platelet aggregation induced by serotype polysaccharides from Streptococcus mutans<\/I>. Infect Immun. 2004;72:2605–2617.","DOI":"10.1128\/IAI.72.5.2605-2617.2004"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Nomura R, Nakano K, Nemoto H, Fujita K, Inagaki S, Takahashi T, et al. Isolation and characterization of Streptococcus mutans<\/I> in heart valve and dental plaque specimens from a patient with infective endocarditis. J Med Microbiol. 2006;55:1135–1140.","DOI":"10.1099\/jmm.0.46609-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Nomura R, Hamada M, Nakano K, Nemoto H, Fujimoto K, Ooshima T. Repeated bacteraemia caused by Streptococcus mutans<\/I> in a patient with Sjogren’s syndrome. J Med Microbiol. 2007;56:988–992.","DOI":"10.1099\/jmm.0.47186-0"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Lu J, Zhang W, Hao Y, Zhu Y. Defect of cell wall construction may shield oral bacteria’s survival in bloodstream and cause infective endocarditis. Med Hypotheses. 2009;73:1055–1057.","DOI":"10.1016\/j.mehy.2009.05.018"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42 Nakano K, Nomura R, Nemoto H, Mukai T, Yoshioka H, Shudo Y, et al. Detection of novel serotype k Streptococcus mutans<\/I> in infective endocarditis patients. J Med Microbiol. 2007;56:1413–1415.","DOI":"10.1099\/jmm.0.47335-0"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, et al. Comparative genomic analyses of Streptococcus mutans<\/I> provide insights into chromosomal shuffling and species-specific content. BMC Genomics. 2009;10:358.","DOI":"10.1186\/1471-2164-10-358"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T15:07:09Z","timestamp":1621436829000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/113\/2\/113_09R24FM\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.09r24fm","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}