{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:03:40Z","timestamp":1768017820084,"version":"3.49.0"},"reference-count":42,"publisher":"Japanese Pharmacological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1254\/jphs.10113fp","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T05:20:24Z","timestamp":1281417624000},"page":"50-62","source":"Crossref","is-referenced-by-count":25,"title":["Mechanism Underlying the Protective Effect of Tempol and N\u03c9-Nitro-L-arginine Methyl Ester on Acoustic Injury: Possible Involvement of c-Jun N-Terminal Kinase Pathway and Connexin26 in the Cochlear Spiral Ligament"],"prefix":"10.1254","volume":"114","author":[{"given":"Reiko","family":"Nagashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyokazu","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Hirose K, Liberman MC. Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea. J Assoc Res Otolaryngol. 2003;4:339–352.","DOI":"10.1007\/s10162-002-3036-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000013846"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1159\/000013847"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00796-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04205-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.12.008"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995;270:1326–1331.","DOI":"10.1126\/science.270.5240.1326"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.012"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08211FP"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00116-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01000-4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Zine A, van de Water TR. The MAPK\/JNK signaling pathway offers potential therapeutic targets for the prevention of acquired deafness. Curr Drug Targets CNS Neurol Disord. 2004;3:325–332.","DOI":"10.2174\/1568007043337166"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Nagashima R, Sugiyama C, Yoneyama M, Kuramoto N, Kawada K, Ogita K. Acoustic overstimulation facilitates the expression of glutamate-cysteine ligase catalytic subunit probably through enhanced DNA binding of activator protein-1 and\/or NF-κ<\/I>B in the murine cochlea. Neurochem Int. 2007;51:209–215.","DOI":"10.1016\/j.neuint.2007.04.023"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Nagashima R, Ogita K. Enhanced biosynthesis of glutathione in the spiral ganglion of the cochlea after in vivo treatment with dexamethasone in mice. Brain Res. 2006;1117:101–108.","DOI":"10.1016\/j.brainres.2006.07.113"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09107FP"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(70)90985-X"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08655.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol Neurootol. 2002;7:171–174.","DOI":"10.1159\/000058305"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(03)00024-4"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09203FP"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Forge A, Becker D, Casalotti S, Edwards J, Marziano N, Nevill G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessment of connexin composition in mammals. J Comp Neurol. 2003;467:207–231.","DOI":"10.1002\/cne.10916"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00157-2"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Yamane H, Nakai Y, Takayama M, Iguchi H, Nakagawa T, Kojima A. Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma. Eur Otorhinolaryngol. 1995;252:504–508.","DOI":"10.1007\/BF02114761"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00660-X"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Chen YS, Tseng FY, Lin KN, Yang TH, Lin-Shiau SY, Hsu CJ. Chronologic changes of nitric oxide concentration in the cochlear lateral wall and its role in noise-induced permanent threshold shift. Laryngoscope. 2008;118:832–836.","DOI":"10.1097\/MLG.0b013e3181651c24"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Michel O, Hess A, Bloch W, Stennert E, Su J, Addicks K. Localization of the NO\/cGMP-pathway in the cochlea of guinea pigs. Hear Res. 1999;133:1–9.","DOI":"10.1016\/S0378-5955(99)00049-0"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00027-6"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.11.020"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300376-JLR200"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Shibata N, Yamada S, Uchida K, Hirano A, Sakoda S, Fujimura H, et al. Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Brain Res. 2004;1019:170–177.","DOI":"10.1016\/j.brainres.2004.05.110"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1021\/bi027172o"},{"issue":"5","key":"33","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1016\/S0021-9258(18)53699-1","volume":"268","year":"1993","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00090-7"},{"issue":"4","key":"35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/jir.1997.17.205","volume":"17","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/1079-9907","issn-type":"print"},{"issue":"1","key":"36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","volume":"68","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Kerr TP, Ross MD, Ernst SA. Cellular localization of Na+<\/SUP>, K+<\/SUP>-ATPase in the mammalian cochlear duct: significance for cochlear fluid balance. Am J Otolaryngol. 1982;3:332–338.","DOI":"10.1016\/S0196-0709(82)80006-9"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4670"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2452"},{"issue":"1","key":"40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.20-01-00043.2000","volume":"20","author":"PIRVOLA U","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci. 2003;23:8596–8607.","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08327FP"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T07:52:32Z","timestamp":1711698752000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/114\/1\/114_10113FP\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.10113fp","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}