{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:45:08Z","timestamp":1773395108055,"version":"3.50.1"},"reference-count":33,"publisher":"Japanese Pharmacological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1254\/jphs.10267fp","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T07:05:36Z","timestamp":1292828736000},"page":"56-62","source":"Crossref","is-referenced-by-count":8,"title":["Pregnenolone Biosynthesis in the Rat Salivary Gland and Its Inhibitory Effect on Secretion"],"prefix":"10.1254","volume":"115","author":[{"given":"Takashi","family":"Miyashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Migiwa","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shinomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan-Ichi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Tsutsui K, Ukena K, Usui M, Sakamoto H, Takase M. Novel brain function: biosynthesis and actions of neurosteroids in neurons. Neurosci Res. 2000;36:261–273.","DOI":"10.1016\/S0168-0102(99)00132-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 1986;232:1004–1007.","DOI":"10.1126\/science.2422758"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90024-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Majewska MD. Neurosteroids: endogenous bimodal modulators of the GABAA<\/SUB> receptor. Mechanism of action and physiological significance. Prog Neurobiol. 1992;38:379–395.","DOI":"10.1016\/0301-0082(92)90025-A"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12905"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nature05324"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00016-L"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00585-X"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00116-8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00117-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2630225100"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Coirini H, Gouézou M, Liere P, Delespierre B, Pianos A, Eychenne B, et al. 3 Beta-hydroxysteroid dehydrogenase expression in rat spinal cord. Neuroscience. 2002;113:883–891.","DOI":"10.1016\/S0306-4522(02)00224-5"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.2.805"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(94)90083-3"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0022-3565(25)21167-3","volume":"279","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90421-M"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1471-4159.1994.63010086.x","volume":"63","year":"1994","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"key":"18","unstructured":"18 Kawaguchi M, Yamagishi H. Coupling of benzodiazepine and GABA(A) receptors in the salivary glands is a factor of drug-induced xerostomia. Int Acad Biomed Drug Res. 1996;11:291–296."},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00628-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09269SC"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704968"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(96)00017-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Kendall DA, McEwen BS, Enna SJ. The influence of ACTH and corticosterone on [3H] GABA receptor binding in rat brain. Brain Res. 1982;236:365–374.","DOI":"10.1016\/0006-8993(82)90721-1"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90023-Y"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90202-9"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.02.043"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1710373"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Cascio C, Russo D, Drago G, Galizzi G, Passantino R, Guarneri R, et al. 17beta-estradiol synthesis in the adult male rat retina. Exp Eye Res. 2007;85:166–172.","DOI":"10.1016\/j.exer.2007.02.008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Vilchis F, Chávez B, Larrea F, Timossi C, Montiel F. The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus). Gen Comp Endocrinol. 2002;126:279–286.","DOI":"10.1016\/S0016-6480(02)00003-5"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2003.11.001"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Morales A, Cuéllar A, Ramírez J, Vilchis F, Díaz-Sánchez V. Synthesis of steroids in pancreas: evidence of cytochrome P-450scc activity. Pancreas. 1999;19:39–44.","DOI":"10.1097\/00006676-199907000-00006"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(92)90225-8"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Cho AK, Melega WP, Kuczenski R, Segal DS. Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse. Synapse. 2001;39:161–166.","DOI":"10.1002\/1098-2396(200102)39:2<161::AID-SYN7>3.0.CO;2-E"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:40:16Z","timestamp":1740786016000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/115\/1\/115_10267FP\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.10267fp","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}