{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:38:12Z","timestamp":1790491092657,"version":"4.1.0"},"reference-count":36,"publisher":"Japanese Pharmacological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1254\/jphs.11072fp","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T05:20:32Z","timestamp":1324444832000},"page":"65-74","source":"Crossref","is-referenced-by-count":26,"title":["Exendin-4 Protects Against Sulfonylurea-Induced \u03b2-Cell Apoptosis"],"prefix":"10.1254","volume":"118","author":[{"given":"Ju-Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Mee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Seo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Il","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haing-Woon","family":"Baik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200201020-00004"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Del Prato S, Pulizzi N. The place of sulfonylureas in the therapy for type 2 diabetes mellitus. Metabolism. 2006;55:S20&ndash;S27.","DOI":"10.1016\/j.metabol.2006.02.003"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.10.2001"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Rosak C. The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents. J Diabetes Complications. 2002;16:123&ndash;132.","DOI":"10.1016\/S1056-8727(01)00207-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2616"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY. Sulfonylurea induced beta-cell apoptosis in cultured human islets. J Clin Endocrinol Metab. 2005;90:501&ndash;506.","DOI":"10.1210\/jc.2004-0699"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Takahashi A, Nagashima K, Hamasaki A, Kuwamura N, Kawasaki Y, Ikeda H, et al. Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase. Diabetes Res Clin Pract. 2007;77:343&ndash;350.","DOI":"10.1016\/j.diabres.2006.12.021"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S455"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008;29:17&ndash;33.","DOI":"10.1210\/er.2007-0039"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Fonseca SG, Burcin M, Gromada J, Urano F. Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol. 2009;9:763&ndash;770.","DOI":"10.1016\/j.coph.2009.07.003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0143416002001823"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.02.001"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Holz GG, Chepurny OG. Glucagon-like peptide-1 synthetic analogues: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem. 2003;10:2471&ndash;2483.","DOI":"10.2174\/0929867033456648"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.11.007"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4093\/kdj.2010.34.1.2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.10.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-06-0148"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Kim JY, Lee SK, Baik HW, Lee KH, Kim HJ, Park KS, et al. Protective effects of glucagon like peptide-1 on HIT-T15 <I>&beta;<\/I> cell apoptosis via ER stress induced by 2-deoxy-D-glucose. Korean Diabetes J. 2008;32:477&ndash;487.","DOI":"10.4093\/kdj.2008.32.6.477"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09178FP"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Sutton R, Peters M, McShane P, Gray DW, Morris PJ. Isolation of rat pancreatic islets by ductal injection of collagenase. Transplantation. 1986;42:689&ndash;691.","DOI":"10.1097\/00007890-198612000-00022"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Steensma DP, Timm M, Witzig TE. Flow cytometric methods for detection and quantification of apoptosis. Methods Mol Med. 2003;85:323&ndash;332.","DOI":"10.1385\/1-59259-380-1:323"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804184200"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Qian L, Zhang S, Xu L, Peng Y. Endoplasmic reticulum stress in beta cells: latent mechanism of secondary sulfonylurea failure in type 2 diabetes? Med Hypotheses. 2008;71:889&ndash;891.","DOI":"10.1016\/j.mehy.2008.07.031"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.763"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Dworacka M, Abramczyk M, Winiarska H, Kuczynski S, Borowska M, Szczawinska K. Disproportionately elevated proinsulin levels in type 2 diabetic patients treated with sulfonylurea. Int J Clin Pharmacol Ther. 2006;44:14&ndash;21.","DOI":"10.5414\/CPP44014"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis. 2006;11:5&ndash;13.","DOI":"10.1007\/s10495-005-3088-0"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.95.33"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Wu KD, Lee WS, Wey J, Bungard D, Lytton J. Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts. Am J Physiol. 1995;269:C775&ndash;C784.","DOI":"10.1152\/ajpcell.1995.269.3.C775"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 East JM. Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure\/function and biology (review). Mol Membr Biol. 2000;17:189&ndash;200.","DOI":"10.1080\/09687680010009646"},{"issue":"2","key":"30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj3190521","volume":"319","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Araki E, Oyadomari S, Mori M. Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med (Maywood). 2003;228:1213&ndash;1217.","DOI":"10.1177\/153537020322801018"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.452"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-1066-4"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Yaekura K, Yada T. [Ca2+]i-reducing action of cAMP in rat pancreatic beta-cells: involvement of thapsigargin-sensitive stores. Am J Physiol. 1998;274:C513&ndash;C521.","DOI":"10.1152\/ajpcell.1998.274.2.C513"},{"key":"35","unstructured":"35 Koh GP, Suh KS, Chon S, Oh SJ, Woo JT, Kim SW, et al. The effect of cAMP-elevating agents on high glucose-induced apoptosis of isolated islets of rat pancreas. Korean Diabetes J. 2004;28:490&ndash;500."},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00458.x"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T15:08:43Z","timestamp":1621436923000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/118\/1\/118_11072FP\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.11072fp","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}