{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:58:16Z","timestamp":1760425096418,"version":"3.40.1"},"reference-count":15,"publisher":"Japanese Pharmacological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1254\/jphs.11161sc","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T05:20:21Z","timestamp":1328246421000},"page":"299-302","source":"Crossref","is-referenced-by-count":5,"title":["Synergistic Interaction Between Fentanyl and a Tramadol:Paracetamol Combination on the Inhibition of Nociception in Mice"],"prefix":"10.1254","volume":"118","author":[{"given":"V\u00edctor","family":"Fern\u00e1ndez-Due\u00f1as","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Poveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Ciruela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Christo PJ, Mazloomdoost D. Cancer pain and analgesia. Ann N Y Acad Sci. 2008;1138:278&ndash;298.","DOI":"10.1196\/annals.1414.033"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Devulder J, Jacobs A, Richarz U, Wiggett H. Impact of opioid rescue medication for breakthrough pain on the efficacy and tolerability of long-acting opioids in patients with chronic non-malignant pain. Br J Anaesth. 2009;103:576&ndash;585.","DOI":"10.1093\/bja\/aep253"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Dhillon S. Tramadol\/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain. Clin Drug Investig. 2010;30:711&ndash;738.","DOI":"10.2165\/11205830-000000000-00000"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3565(25)11227-5","volume":"260","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Raffa RB, Walker EA, Sterious SN. Opioid receptors and acetaminophen (paracetamol). Eur J Pharmacol. 2004;503:209&ndash;210.","DOI":"10.1016\/j.ejphar.2004.08.055"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.01.023"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Tallarida RJ, Raffa RB. Testing for synergism over a range of fixed ratio drug combinations: replacing the isobologram. Life Sci. 1996;58:PL23&ndash;PL28.","DOI":"10.1016\/0024-3205(95)02271-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Lee EY, Lee EB, Park BJ, Lee CK, Yoo B, Lim MK, et al. Tramadol 37.5-mg\/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. Clin Ther. 2006;28:2052&ndash;2060.","DOI":"10.1016\/j.clinthera.2006.12.019"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3565(24)29450-7","volume":"298","author":"TALLARIDA R J","year":"2001","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00495865"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0022-3565(24)37902-9","volume":"287","author":"PUIG M M","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Gong YH, Yu XR, Liu HL, Yang N, Zuo PP, Huang YG. Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats. Acta Anaesthesiol Taiwan. 2011;49:16&ndash;20.","DOI":"10.1016\/j.aat.2011.01.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.12.010"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.02.011"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Langley PC, Patkar AD, Boswell KA, Benson CJ, Schein JR. Adverse event profile of tramadol in recent clinical studies of chronic osteoarthritis pain. Curr Med Res Opin. 2010;26:239&ndash;251.","DOI":"10.1185\/03007990903426787"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T20:05:11Z","timestamp":1742414711000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jphs\/118\/2\/118_11161SC\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.11161sc","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"type":"print","value":"1347-8613"},{"type":"electronic","value":"1347-8648"}],"subject":[],"published":{"date-parts":[[2012]]}}}