{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:50:18Z","timestamp":1791474618433,"version":"4.3.4"},"reference-count":25,"publisher":"Japanese Pharmacological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pharmacol Sci"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1254\/jphs.11228sc","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T03:13:04Z","timestamp":1334718784000},"page":"97-101","source":"Crossref","is-referenced-by-count":31,"title":["<I>N<\/I>-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice"],"prefix":"10.1254","volume":"119","author":[{"given":"Nobuaki","family":"Egashira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomiko","family":"Niki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Rasmussen SA, Eisen JL. The epidemiology and clinical features of obsessive-compulsive disorder. Psychiatr Clin North Am. 1992;15:743–758.","DOI":"10.1016\/S0193-953X(18)30205-3"},{"key":"2","doi-asserted-by":"crossref","unstructured":"1 Rasmussen SA, Eisen JL. The epidemiology and clinical features of obsessive-compulsive disorder. Psychiatr Clin North Am. 1992;15:743–758.","DOI":"10.1016\/S0193-953X(18)30205-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"2 Sasson Y, Zohar J, Chopra M, Lustig M, Iancu I, Hendler T. Epidemiology of obsessive-compulsive disorder: a world view. J Clin Psychiatry. 1997;58:7–10.","DOI":"10.1159\/000061358"},{"key":"4","doi-asserted-by":"crossref","unstructured":"2 Sasson Y, Zohar J, Chopra M, Lustig M, Iancu I, Hendler T. Epidemiology of obsessive-compulsive disorder: a world view. J Clin Psychiatry. 1997;58:7–10.","DOI":"10.1159\/000061358"},{"key":"5","doi-asserted-by":"crossref","unstructured":"3 Greist JH, Bandelow B, Hollander E, Marazziti D, Montgomery SA, Nutt DJ, et al.; World Council of Anxiety. WCA recommendations for the long-term treatment of obsessive-compulsive disorder in adults. CNS Spectr. 2003;8:7–16.","DOI":"10.1017\/S1092852900006908"},{"key":"6","doi-asserted-by":"crossref","unstructured":"4 Goodman WK, Price LH, Rasmussen SA, Delgado PL, Heninger GR, Charney DS. Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch Gen Psychiatry. 1989;46:36–44.","DOI":"10.1001\/archpsyc.1989.01810010038006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"4 Goodman WK, Price LH, Rasmussen SA, Delgado PL, Heninger GR, Charney DS. Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch Gen Psychiatry. 1989;46:36–44.","DOI":"10.1001\/archpsyc.1989.01810010038006"},{"key":"8","doi-asserted-by":"crossref","unstructured":"5 Koran LM, Gamel NN, Choung HW, Smith EH, Aboujaoude EN. Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation. J Clin Psychiatry. 2005;66:515–520.","DOI":"10.4088\/JCP.v66n0415"},{"key":"9","doi-asserted-by":"crossref","unstructured":"6 Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology. 2004;174:530–538.","DOI":"10.1007\/s00213-004-1847-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"7 Chakrabarty K, Bhattacharyya S, Christopher R, Khanna S. Glutamatergic dysfunction in OCD. Neuropsychopharmacology. 2005;30:1735–1740.","DOI":"10.1038\/sj.npp.1300733"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300733"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181c856de"},{"key":"13","doi-asserted-by":"crossref","unstructured":"8 Stewart SE, Jenike EA, Hezel DM, Stack DE, Dodman NH, Shuster L, et al. A single-blinded case-control study of memantine in severe obsessive-compulsive disorder. J Clin Psychopharmacol. 2010;30:34–39.","DOI":"10.1097\/JCP.0b013e3181c856de"},{"key":"14","doi-asserted-by":"crossref","unstructured":"9 Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine\/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci. 2005;25:6389–6393.","DOI":"10.1523\/JNEUROSCI.1007-05.2005"},{"key":"15","doi-asserted-by":"crossref","unstructured":"9 Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine\/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci. 2005;25: 6389–6393.","DOI":"10.1523\/JNEUROSCI.1007-05.2005"},{"key":"16","doi-asserted-by":"crossref","unstructured":"10 Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci. 2003;6:743–749.","DOI":"10.1038\/nn1069"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nn1069"},{"key":"18","doi-asserted-by":"crossref","unstructured":"11 Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, et al. N<\/I>-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl). 2006;184:254–256.","DOI":"10.1007\/s00213-005-0246-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.68.65"},{"key":"20","doi-asserted-by":"crossref","unstructured":"12 Ichimaru Y, Egawa T, Sawa A. 5-HT1A<\/SUB>-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice. Jpn J Pharmacol. 1995; 68:65–70.","DOI":"10.1254\/jjp.68.65"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/01.fbp.0000236266.34182.1c"},{"key":"22","doi-asserted-by":"crossref","unstructured":"13 Harasawa T, Ago Y, Itoh S, Baba A, Matsuda T. Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice. Behav Pharmacol. 2006;17:637–640.","DOI":"10.1097\/01.fbp.0000236266.34182.1c"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.01.035"},{"key":"24","doi-asserted-by":"crossref","unstructured":"14 Egashira N, Okuno R, Harada S, Matsushita M, Mishima K, Iwasaki K, et al. Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder. Eur J Pharmacol. 2008;586:164–170.","DOI":"10.1016\/j.ejphar.2008.01.035"},{"key":"25","doi-asserted-by":"crossref","unstructured":"15 LaRowe SD, Mardikian P, Malcolm R, Myrick H, Kalivas P, McFarland K, et al. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addict. 2006;15:105–110.","DOI":"10.1080\/10550490500419169"}],"container-title":["Journal of Pharmacological Sciences"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T15:09:06Z","timestamp":1621436946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jphs\/119\/1\/119_11228SC\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1254\/jphs.11228sc","relation":{},"ISSN":["1347-8613","1347-8648"],"issn-type":[{"value":"1347-8613","type":"print"},{"value":"1347-8648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}