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Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats. J Cardiovasc Pharmacol. 2005;46:505\u2013512.","DOI":"10.1097\/01.fjc.0000177981.91434.ba"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Shinozaki K, Nishio Y, Ayajiki K, Yoshida Y, Masada M, Kashiwagi A, et al. Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production. J Cardiovasc Pharmacol. 2007;49:122\u2013130.","DOI":"10.1097\/FJC.0b013e31802f5895"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Kobayashi M, Kobayashi K, Hara K, Higashi T, Yanaka H, Yagi S, et al. Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. 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Biosynthesis of nitric oxide: dependence on pteridine metabolism. Rev Physiol Biochem Pharmacol. 1996;127:97\u2013135.","DOI":"10.1007\/BFb0048266"},{"key":"27","unstructured":"27 Kontos HA, Kontos MC. Role of products of univalent reduction of oxygen in hypertensive vascular injury. In: Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis, and management. New York: Raven Press; 1995. p. 685\u2013696."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Kaufman S, Kapatos G, Rizzo WB, Schulman JD, Tamarkin L, Van Loon GR. Tetrahydropterin therapy for hyperphenylalaninemia caused by defective synthesis of tetrahydrobiopterin. Ann Neurol. 1983;14:308\u2013315.","DOI":"10.1002\/ana.410140309"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Cai S, Khoo J, Channon KM. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. 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