{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:50:51Z","timestamp":1777585851582,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Mass Spectrom (Chichester)"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    The inclusion complexes of four ligands binding to cyclodextrins (CDs) were studied by electrospray ionization mass spectrometry (ESI-MS) and the dissociation constants of the complexes were obtained. The 1:1 stoichiometric inclusion complex was found in the system of CD and fenbufen or aspirin. The obtained K\n                    <jats:sub>D<\/jats:sub>\n                    values of the inclusion complexes of fenbufen binding to \u03b1-CD and to \u03b2-CD are 4.38 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 2.12 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. The K\n                    <jats:sub>D<\/jats:sub>\n                    values of the inclusion complexes of \u03b1-CD-aspirin and \u03b2-CD-aspirin are 3.33 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.83 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. A non-linear least squares regression method was applied to validate the results which were consistent with each other. For the system of tetracycline hydrochloride and CD, the 1:1 and 1:2 stoichiometric inclusion complexes were found in the mass spectra. The K\n                    <jats:sub>D,1<\/jats:sub>\n                    and K\n                    <jats:sub>D,2<\/jats:sub>\n                    values of the 1:1 and 1:2 stoichiometric inclusion complexes of \u03b1-CD and tetracycline hydrochloride are 4.47 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 6.51 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively, and those of \u03b2-CD and tetracycline hydrochloride are 2.26 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 8.57 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. For the system of norfloxacin and CD, besides the 1:1 and 1:2 inclusion complexes, the 1:3 stoichiometric inclusion complex was also found. The K\n                    <jats:sub>D,1<\/jats:sub>\n                    , K\n                    <jats:sub>D,2<\/jats:sub>\n                    and K\n                    <jats:sub>D,3<\/jats:sub>\n                    of \u03b1-CD and norfloxacin inclusion complexes are 4.61 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 6.05 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.45 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. The three K\n                    <jats:sub>D<\/jats:sub>\n                    values of \u03b2-CD and norfloxacin are 1.96 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 4.93 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.15 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively.\n                  <\/jats:p>","DOI":"10.1255\/ejms.818","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T07:23:54Z","timestamp":1171610634000},"page":"291-299","source":"Crossref","is-referenced-by-count":7,"title":["Determination of Dissociation Constants of Cyclodextrin\u2014Ligand Inclusion Complexes by Electrospray Ionization Mass Spectrometry"],"prefix":"10.1177","volume":"12","author":[{"given":"Huarong","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P.R. 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