{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:49:06Z","timestamp":1785894546484,"version":"3.56.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:p>Background Fragments of parathyroid hormone (PTH) have been identified (amino acids 7-84) which may interfere with commercially available 'intact molecule' PTH assays. Novel assays which employ an antibody directed to the first seven amino acids of the N-terminus of PTH are thought to be free from cross-reactivity with the 7-84 fragments, and therefore measure true 'whole molecule' PTH. Transplant recipients (as well as those in end-stage renal failure) have been reported to have elevated levels of 'intact' in comparison with 'whole molecule' PTH.<\/jats:p>\n                  <jats:p>Methods PTH concentrations were assessed in serum samples obtained from female renal transplant recipients previously classified as either having hyperparathyroid ( n = 14) or adynamic bone disease ( n = 14) by transiliac crest bone biopsy. PTH was measured as 'whole molecule' (Scantibodies 'whole molecule' PTH) and 'intact' (DPC Immulite 2000 intact PTH and Scantibodies total PTH).<\/jats:p>\n                  <jats:p>Results Scantibodies 'whole molecule' PTH (all-subject mean 48\u00b77 ng\/L, \u00b1 53\u00b70) were significantly lower than DPC intact (83\u00b75 ng\/L, \u00b1 88\u00b71; P \u22640001) and Scantibodies total PTH (80\u00b75 ng\/L, \u2264 92\u00b74; P \u2264 0\u00b70001). However, the differences between the 'whole molecule' and 'intact' measurements were similar across the two patient groups, and reflected the lower reference range employed by the 'whole molecule' assay.<\/jats:p>\n                  <jats:p>Conclusion The 'whole molecule' PTH assay was unable to discriminate between the two patient populations and provided very little additional clinical information to that obtained from the intact PTH assays.<\/jats:p>","DOI":"10.1258\/0004563021902044","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T05:28:56Z","timestamp":1034746136000},"page":"314-317","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of intact and 'whole molecule' parathyroid hormone assays in                patients with histologically confirmed post-renal transplant                osteodystrophy"],"prefix":"10.1177","volume":"39","author":[{"given":"Ian M","family":"Godber","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Nottingham City Hospital, Hucknall\r                  Road, Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelle R","family":"Parker","sequence":"additional","affiliation":[{"name":"Division of Mineral Metabolism, Nottingham City Hospital, Hucknall\r                  Road, Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Lawson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Nottingham City Hospital, Hucknall\r                  Road, Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Hitch","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Nottingham City Hospital, Hucknall\r                  Road, Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine J","family":"Porter","sequence":"additional","affiliation":[{"name":"Nottingham Renal Unit, Nottingham City Hospital, Hucknall Road,\r                  Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D","family":"Roe","sequence":"additional","affiliation":[{"name":"Nottingham Renal Unit, Nottingham City Hospital, Hucknall Road,\r                  Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael JD","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Nottingham Renal Unit, Nottingham City Hospital, Hucknall Road,\r                  Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Hosking","sequence":"additional","affiliation":[{"name":"Division of Mineral Metabolism, Nottingham City Hospital, Hucknall\r                  Road, Nottingham, NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,5,1]]},"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0004563021902044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0004563021902044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:52:01Z","timestamp":1777377121000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0004563021902044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5,1]]}},"alternative-id":["10.1258\/0004563021902044"],"URL":"https:\/\/doi.org\/10.1258\/0004563021902044","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,1]]}}}