{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:09:18Z","timestamp":1792696158377,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:p>\n                    A 19-year-old man who developed extensive oesophageal lye (Alkali) stricture and received long-term enteral nutrition (eight months) with a jejunostomy tube developed macrocytic anaemia (Hb: 41 g\/L) with leucopenia (white blood cell [WBC]: 3.0 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L). The patient's serum vitamin B12, folate, iron and liver function tests were normal. Bone marrow examination revealed gross erythroid hyperplasia and cytoplasmic vacuolization of erythroid and myeloid elements. Further investigations revealed low serum copper (0.3 \u03bcmol\/L) and ceruloplasmin concentrations (&lt;30 mg\/L) with marginally low normal serum concentration of red cell peroxidase (13 U\/gHb), establishing the diagnosis of copper deficiency anaemia. The anaemia and leucopenia responded intermittently to intravenous copper therapy, but the serum copper concentration dropped when intravenous copper therapy was withdrawn. Enteral jejunostomy copper supplementation failed to maintain adequate serum copper concentrations. After stabilizing the general condition of the patient, a pharyngo-gastric anastamosis was performed and normal oral diet commenced, which restored normal serum copper concentration. This case report suggests that copper supplements in the form of copper sulphate are not adequately absorbed when administered through a jejunostomy tube.\n                  <\/jats:p>","DOI":"10.1258\/0004563053857879","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T05:32:44Z","timestamp":1115875964000},"page":"227-231","source":"Crossref","is-referenced-by-count":23,"title":["Acquired copper deficiency following prolonged jejunostomy feeds"],"prefix":"10.1177","volume":"42","author":[{"given":"S","family":"Jayakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P D","family":"Micallef-Eynaud","sequence":"additional","affiliation":[{"name":"Department of Haematology, Crosshouse Hospital, Kilmarnock KA2 0BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T D B","family":"Lyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Cramb","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham B15 2TH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Jilaihawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hairmyres Hospital, East Kilbride G75 8RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,5,1]]},"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0004563053857879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0004563053857879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:08Z","timestamp":1777377188000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0004563053857879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5,1]]}},"alternative-id":["10.1258\/0004563053857879"],"URL":"https:\/\/doi.org\/10.1258\/0004563053857879","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,1]]}}}