{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:49:04Z","timestamp":1781376544970,"version":"3.54.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>Background: The luteinizing hormone\/follicle stimulating hormone (LH\/FSH) ratio is often requested to help diagnose polycystic ovarian syndrome (PCOS) despite a recent consensus recommending against its use. This study aimed to compare the variability of the LH\/FSH ratio in PCOS with that of normal menstruating women over a full cycle in order to establish the diagnostic utility, or otherwise, of the test.<\/jats:p>\n                  <jats:p>Methods: Twelve women with PCOS and 11 matched controls had blood collected at four-day intervals on 10 consecutive occasions over a complete menstrual cycle.<\/jats:p>\n                  <jats:p>Results: The median LH\/FSH ratio for individual subjects did not differ significantly between the PCOS and the non-affected group (1.6 versus 1.2, P=0.14). Only 7.6% of samples from PCOS patients had an LH\/FSH ratio above three, compared with 15.6% of samples from normal subjects.<\/jats:p>\n                  <jats:p>Conclusion: This study confirms that measurement of the LH\/FSH ratio is of limited use in the diagnosis of PCOS.<\/jats:p>","DOI":"10.1258\/000456306776865188","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T19:31:51Z","timestamp":1146079911000},"page":"217-219","source":"Crossref","is-referenced-by-count":42,"title":["The LH\/FSH ratio has little use in diagnosing polycystic ovarian syndrome"],"prefix":"10.1177","volume":"43","author":[{"given":"Li Wei","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Hull, Hull, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Jayagopal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hull, Hull, UK; Department of Medicine, York Hospital, York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Hull Royal Infirmary, Hull, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Holding","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hull Royal Infirmary, Hull, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L","family":"Atkin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hull, Hull, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456306776865188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456306776865188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:14Z","timestamp":1777377254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/000456306776865188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5,1]]}},"alternative-id":["10.1258\/000456306776865188"],"URL":"https:\/\/doi.org\/10.1258\/000456306776865188","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,1]]}}}