{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:53:05Z","timestamp":1777434785914,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:p>Background: Protein 1 (P1)\/Clara cell 16 kDa protein (CC16, previously named CC10), a potentially immunosuppressive protein secreted by non-ciliated cells of the tracheobronchial epithelium, has been found to be a new useful lung-specific biomarker in several pathological lung conditions. Particularly, urinary P1 (uP1) may reflect the altered lung functions in pneumoconiosis.<\/jats:p>\n                  <jats:p>\n                    Methods: We investigated the relationship between uP1 values and lung functions in 31 non-smoking pneumoconiotic males (mean age 73 years) with a history of dust exposure work in shipbuilding. The protein was measured using an originally prepared enzyme-linked immunosorbent assay system. The forced expiratory volume in 1 s % (FEV\n                    <jats:sub>1.0<\/jats:sub>\n                    %) and % vital capacity (%VC) were tested with a spirometer.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: The mean values of uP1 were 4.62 \u00b1 4.82 (mean \u00b1 standard deviation) ng\/mol creatinine. A univariable correlation test showed a significant positive correlation between uP1 and %VC ( r = 0.356, P = 0.049). Also, a multiple regression analysis, when adjusted for age, disease duration, FEV\n                    <jats:sub>1.0<\/jats:sub>\n                    % and %VC, showed a significant correlation of uP1 with %VC ( \u03b2 = 0.467, P = 0.030).\n                  <\/jats:p>\n                  <jats:p>Conclusion: The results suggest that a decreased uP1, corroborated by a decreased %VC, may be the result of damage to secretory cells. Measurement of uP1 may become a possible index of fibrotic changes in pneumoconiosis.<\/jats:p>","DOI":"10.1258\/000456307782268110","type":"journal-article","created":{"date-parts":[[2007,10,21]],"date-time":"2007-10-21T20:29:39Z","timestamp":1192998579000},"page":"560-562","source":"Crossref","is-referenced-by-count":7,"title":["Urinary protein 1\/Clara cell 16 concentrations and lung functions in male subjects with pneumoconiosis"],"prefix":"10.1177","volume":"44","author":[{"given":"Kazuhiko","family":"Kotani","sequence":"first","affiliation":[{"name":"Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haosheng","family":"Mu","sequence":"additional","affiliation":[{"name":"Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Kurozawa","sequence":"additional","affiliation":[{"name":"Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456307782268110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456307782268110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:48Z","timestamp":1777377288000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/000456307782268110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11,1]]}},"alternative-id":["10.1258\/000456307782268110"],"URL":"https:\/\/doi.org\/10.1258\/000456307782268110","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,1]]}}}