{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:53:02Z","timestamp":1777434782638,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:p>The clinical diagnosis of mixed cryoglobulinaemia is difficult due to heterogeneity in presentation. Symptoms include the classical triad of purpura, arthralgia and weakness, with one or more other organs involved. We discuss a case of cryoglobulinaemia that presented with sensory motor neuropathy and with features of mononeuritis multiplex syndrome, but which lacked other classical features. Laboratory testing revealed a profile typical of mixed cryoglobulins: immunoglobulin M (IgM) paraprotein, low fourth carbon (C4) and positive rheumatoid factor. Subsequent investigations failed to reveal an underlying infectious or neoplastic cause. This case demonstrates the need to include cryoglobulinaemia in the differential diagnosis for peripheral neuropathy, and the critical importance of using the correct collection procedure to isolate cryoglobulins.<\/jats:p>","DOI":"10.1258\/000456307782268138","type":"journal-article","created":{"date-parts":[[2007,10,21]],"date-time":"2007-10-21T20:29:39Z","timestamp":1192998579000},"page":"566-569","source":"Crossref","is-referenced-by-count":4,"title":["A case study of mixed cryoglobulinaemia associated with peripheral neuropathy"],"prefix":"10.1177","volume":"44","author":[{"given":"R D","family":"Wheeler","sequence":"first","affiliation":[{"name":"Protein Reference Unit, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sharma","sequence":"additional","affiliation":[{"name":"Centre for Clinical Neuroscience, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Groves","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Institute of Neurology UCL, Queen Square, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Wren","sequence":"additional","affiliation":[{"name":"Centre for Clinical Neuroscience, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Protein Reference Unit, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456307782268138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/000456307782268138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:48Z","timestamp":1777377288000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/000456307782268138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11,1]]}},"alternative-id":["10.1258\/000456307782268138"],"URL":"https:\/\/doi.org\/10.1258\/000456307782268138","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,1]]}}}