{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:25:02Z","timestamp":1759962302057},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"unspecified","delay-in-days":1315,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>A Th1\/Th2 cytokine imbalance with a predominance of Th1 cytokines has been suggested to be of pathogenic importance in Wegener\u2019s granulomatosis. To evaluate the role of Th1\/Th2 cytokines in Wegener\u2019s granulomatosis, the subsets of Th1, Th2, Tc1 and Tc2 cells from patients with active Wegener\u2019s granulomatosis were examined by intracellular cytokine flow cytometry. The population of Tc1 cells (72.0 \u00b1 14.4 per cent) in Wegener\u2019s granulomatosis was significantly increased compared with Tc1 cells (37.3 \u00b1 14.6 per cent) in control (<jats:italic>p<\/jats:italic>&lt;0.05). Th1, Th2 and Tc2 cells in Wegener\u2019s granulomatosis were not significantly increased compared with the control cells. These results indicate that the predominance of Tc1 cells might contribute to the mechanism of the pathogenesis of Wegener\u2019s granulomatosis.<\/jats:p>","DOI":"10.1258\/00222150260171597","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T09:28:56Z","timestamp":1034760536000},"page":"605-609","source":"Crossref","is-referenced-by-count":7,"title":["Th1 and Th2 CD4<sup>+<\/sup> T cells and Tc1 and Tc2 CD8<sup>+<\/sup> T cells of patients with Wegener\u2019s granulomatosis"],"prefix":"10.1017","volume":"116","author":[{"given":"Nobuo","family":"Ohta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fukase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Fuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,3,8]]},"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215102001822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:50:04Z","timestamp":1557190204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215102001822\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S0022215102001822"],"URL":"https:\/\/doi.org\/10.1258\/00222150260171597","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}