{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:19:25Z","timestamp":1775881165836,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"unspecified","delay-in-days":1131,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is an accepted cause of chronic active gastritis and has a major causative role in peptic ulceration. It is a gastric carcinogen. Its role in non-ulcer dyspepsia (NUD) is less clear; yet 50 per cent of patients with NUD are infected with <jats:italic>H pylori<\/jats:italic>. <jats:italic>H pylori<\/jats:italic> has been investigated in several other organ systems, but has not been investigated extensively in squamous cell carcinoma of the upper aerodigestive tract, a region which could be directly exposed to the bacterium by gastro-oesophageal reflux (GOR).<\/jats:p><jats:p>In this study 61 patients with severe laryngeal dysplasia or frank carcinoma of the head and neck are striated by age, investigated for the presence of antibodies to <jats:italic>H pylori<\/jats:italic> and compared to age and sex matched controls.<\/jats:p><jats:p>In the age group of 46\u201361 years, the presence of <jats:italic>H pylori<\/jats:italic> antibodies was marginally greater in the experimental (63.0 per cent) than the control group (40.7 per cent) (Pearson Chi square <jats:italic>p<\/jats:italic> = 0.055, Fisher 2-sided exact test <jats:italic>p<\/jats:italic>= 0.066). When combining this age group with the younger age group and thereby creating two roughly equal groups (n = 31 and n = 30) there was also a statistical trend towards increased positivity in the experimental group. These findings are discussed in the light of other studies with gastro-oesophageal reflux disease (GORD).<\/jats:p>","DOI":"10.1258\/002221503762624558","type":"journal-article","created":{"date-parts":[[2003,3,7]],"date-time":"2003-03-07T04:58:41Z","timestamp":1047013121000},"page":"118-121","source":"Crossref","is-referenced-by-count":26,"title":["The prevalence of <i>Helicobacter pylori<\/i> infection in malignant and premalignant conditions of the head and neck"],"prefix":"10.1017","volume":"117","author":[{"given":"J. S.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Prior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lavy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,3,8]]},"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215103000276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T23:34:49Z","timestamp":1557185689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215103000276\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0022215103000276"],"URL":"https:\/\/doi.org\/10.1258\/002221503762624558","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}