{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:56:00Z","timestamp":1792058160344,"version":"4.4.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"unspecified","delay-in-days":584,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>There has been a steady increase in the number of cases of methicillin-resistant<jats:italic> Staphylococcus aureus <\/jats:italic> (MRSA) otorrhoea; this is a growing concern. The purpose of this study was to evaluate the efficacy of topical vancomycin treatment in patients with MRSA otorrhoea. Fifty-five patients with MRSA otorrhoea were prospectively enrolled into the study. Thirty-five patients were treated with vancomycin eardrops as outpatients. The concentration of the locally prepared vancomycin solution was 25 mg\/ml. The dose of vancomycin was two drops three times daily for 10 days. As a control group, 20 patients were treated with gentamicin 0.3% solution. Data were analysed by the Mann-Whitney <jats:italic>U<\/jats:italic> test to compare the efficacy of vancomycin eardrops and gentamicin eardrops. In the vancomycin group, the otorrhoea was significantly reduced in 33 ears (94%); in the gentamicin group, in four ears (20 per cent); this reduction was statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.03). The use of topical vancomycin treatment was effective for patients with MRSA otorrhoea refractory to conventional antibiotic treatment.<\/jats:p>","DOI":"10.1258\/0022215041917899","type":"journal-article","created":{"date-parts":[[2004,9,22]],"date-time":"2004-09-22T04:03:25Z","timestamp":1095825805000},"page":"645-647","source":"Crossref","is-referenced-by-count":27,"title":["Topical vancomycin for chronic suppurative otitis media with methicillin-resistant<i> Staphylococcus aureus<\/i> otorrhoea"],"prefix":"10.1017","volume":"118","author":[{"given":"Chul Ho","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pa-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2006,3,8]]},"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215104001719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:41:19Z","timestamp":1557175279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215104001719\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0022215104001719"],"URL":"https:\/\/doi.org\/10.1258\/0022215041917899","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}