{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:37:05Z","timestamp":1777883825071,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2000,10,1]]},"abstract":"<jats:p>Vaccination of young children with diphtheria, tetanus, poliomyelitis and pertussis (DTPoP) vaccine is effective in preventing outbreaks of whooping cough but adverse events sometimes occur. This pilot study shows that in freely-moving rats, multiple treatment with DTPoP (at day 0 and day 5, 6 ml\/kg i.v.) increased heart rate (HR) for 5 days after the first treatment and decreased diastolic blood pressure (DBP) for at least 26 days after the first treatment and inhibited the circadian rhythm of HR and DBP for at least 10 days. DTPo vaccine, containing no pertussis vaccine, was free of such effects. Thus, in rats, the pertussis component of DTPoP acts on the cardiovascular system and disturbs its circadian rhythm. The contribution of these findings to clinical adverse effects is as yet unknown and needs further research.<\/jats:p>","DOI":"10.1258\/002367700780387697","type":"journal-article","created":{"date-parts":[[2007,4,8]],"date-time":"2007-04-08T19:32:28Z","timestamp":1176060748000},"page":"399-402","source":"Crossref","is-referenced-by-count":4,"title":["Disturbance of cardiovascular circadian rhythms by pertussis vaccine in freely-moving rats"],"prefix":"10.1177","volume":"34","author":[{"given":"W.","family":"Vleeming","sequence":"first","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"van de Kuil","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"te Biesebeek","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"van der Laan","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"de Wildt","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G. C.","family":"van Amsterdam","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Laboratory of Health Effects Research, PO Box 1, NL 3720 BA Bilthoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,10,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367700780387697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367700780387697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:00:13Z","timestamp":1777600813000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367700780387697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10,1]]}},"alternative-id":["10.1258\/002367700780387697"],"URL":"https:\/\/doi.org\/10.1258\/002367700780387697","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10,1]]}}}