{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:37:10Z","timestamp":1777883830950,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p>\n                    Effective plasma concentrations of propofol, thiopentone and ketamine were determined at different endpoints in a study with randomized, crossover design in nine New Zealand White rabbits. A continuous infusion was used (30 ml\/h) with concentrations of 10 mg\/ml for propofol, 25 mg\/ml for thiopentone and 20 mg\/ml for ketamine. The endpoints were loss of the righting reflex, loss of purposeful reactions to tail clamping (as an example of a peripheral pain stimulus) or to intranostril insufflation of ammonia vapour (as an example of a central reflex stimulus), and the recovery of these reflexes and reactions. According to the ED\n                    <jats:sub>50<\/jats:sub>\n                    values the potency ratios of propofol, thiopentone and ketamine were at the loss of righting reflex 1:1.8:1.2, at the loss of reaction to ammonia vapour 1:1.5:1.6, and at the loss of reaction to tail clamping 1:1.5:3.9, respectively. Recovery was significantly faster after propofol than after thiopentone and ketamine. Measuring the effective plasma concentrations of intravenous anaesthetics provides a method of relating dose to effect, but there still remains a variable gap between plasma concentration and effect.\n                  <\/jats:p>","DOI":"10.1258\/002367700780578037","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T19:40:53Z","timestamp":1177616453000},"page":"36-45","source":"Crossref","is-referenced-by-count":7,"title":["Potency of propofol, thiopentone and ketamine at various endpoints in New Zealand White rabbits"],"prefix":"10.1177","volume":"34","author":[{"given":"S. T.","family":"Mustola","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, South Carelia Central Hospital, Lappeenranta, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G. F.","family":"Rorarius","sequence":"additional","affiliation":[{"name":"Medical School, University of Tampere and Department of Anaesthesiology, Tampere University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Baer","sequence":"additional","affiliation":[{"name":"Medical School, University of Tampere and Department of Anaesthesiology, Tampere University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Harmoinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Tampere University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,1,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367700780578037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367700780578037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:00:41Z","timestamp":1777600841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367700780578037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"alternative-id":["10.1258\/002367700780578037"],"URL":"https:\/\/doi.org\/10.1258\/002367700780578037","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}