{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:37:37Z","timestamp":1777883857356,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>Atrichia with papular lesions (APL) is a rare form of hair loss with an autosomal recessive mode of inheritance that is characterized by the absence of normal hair follicles, and formation of intradermal cystic structures. Mutations in the hairless ( hr) gene in mice and humans have been implicated in the development of this phenotype. Hairless is a putative transcription factor containing a single zinc-finger DNA binding domain, with restricted expression in brain and skin. Here, we describe the complete hr cDNA sequence from the rhesus macaque ( Macaca mulatta) and report the identification of a compound heterozygous mutation in a hairless rhesus macaque born from unrelated parents. Cutaneous biopsy samples from the affected macaque revealed abnormalities, including the replacement of normal hair follicles with dermal cysts and comedones, reminiscent of the skin phenotype observed in hairless mice and humans with APL.<\/jats:p>","DOI":"10.1258\/0023677021911777","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T05:28:56Z","timestamp":1034746136000},"page":"61-67","source":"Crossref","is-referenced-by-count":16,"title":["Atrichia with papular lesions resulting from mutations in the rhesus                macaque (\n                    <i>Macaca mulatta<\/i>\n                    )\n                    <i>hairless<\/i>\n                    gene"],"prefix":"10.1177","volume":"36","author":[{"given":"Wasim","family":"Ahmad","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Columbia University, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion S.","family":"Ratterree","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Tulane Regional Primate Research\r                  Center, Covington, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei A.","family":"Panteleyev","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Columbia University, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent M.","family":"Aita","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Columbia University, New York and Department of Genetics & Development, Columbia University, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Sundberg","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"Christiano","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Columbia University, New York and Department of Genetics & Development, Columbia University, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0023677021911777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0023677021911777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:01:55Z","timestamp":1777600915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0023677021911777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["10.1258\/0023677021911777"],"URL":"https:\/\/doi.org\/10.1258\/0023677021911777","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]}}}