{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:43:41Z","timestamp":1777884221188,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1981,10,1]],"date-time":"1981-10-01T00:00:00Z","timestamp":370742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1981,10,1]]},"abstract":"<jats:p>\n                    The oral acute toxicity of 3 \u03b2-adrenoceptor stimulants, 2 \u03b2-adrenoceptor blockers, and 2 anti-gastric ulcer drugs was studied in 8-week old, SD-JCL rats and ICR-JCL mice, fasted overnight for 17-20 hours. The results were compared with those from rats and mice allowed to feed normally. The order of the fed : fasted ratio of LD\n                    <jats:sub>50<\/jats:sub>\n                    values in rats was pirenzepin &lt; propantheline &lt; pindolol &lt; salbutamol &lt; orciprenaline &lt; fenoterol &lt; bunitrolol, and was in the range 1\u00b73-4\u00b77. The increased toxicity in fasted animals was considered to be related to acceleration in gastric emptying and intestinal absorption, but not to a general change in the condition of the test system or a decrease in the detoxification ability of the liver because after intraperitoneal administration acute toxicity was similar in fed and fasted rats.\n                  <\/jats:p>","DOI":"10.1258\/002367781780952933","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T00:04:34Z","timestamp":1182125074000},"page":"359-364","source":"Crossref","is-referenced-by-count":16,"title":["The effect of fasting on oral acute toxicity of drugs in rats and mice"],"prefix":"10.1177","volume":"15","author":[{"given":"Alexander","family":"Kast","sequence":"first","affiliation":[{"name":"Department of Experimental Pathology, Boehringer Ingelheim GmbH, Pharma-Research Japan, 103 Takada, Yato, Kawanishi, Hyogo 666-01, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology, Boehringer Ingelheim GmbH, Pharma-Research Japan, 103 Takada, Yato, Kawanishi, Hyogo 666-01, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,10,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367781780952933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367781780952933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:17:08Z","timestamp":1777601828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367781780952933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,10,1]]}},"alternative-id":["10.1258\/002367781780952933"],"URL":"https:\/\/doi.org\/10.1258\/002367781780952933","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,10,1]]}}}