{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:07:27Z","timestamp":1758280047721,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1986,10,1]],"date-time":"1986-10-01T00:00:00Z","timestamp":528508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1986,10,1]]},"abstract":"<jats:p> In this paper the production of the R\/APfd-j\/j strain which is congenic with the R\/APfd strain is reported. The R\/APfd-j\/j completely lacks hepatic bilirubin UDP-glucuronyltransferase activity, as do our GUNNXR\/Pfd-j\/j rat strain and various other stocks of GUNN rats (j\/j) described in the literature. Our recombinant inbred strain GUNNXR\/Pfd-j\/j was produced from non-inbred GUNN (j\/j) rats. This GUNNXR\/Pfd-j\/j rat was used as a donor of the jaundice gene j, the R\/APfd rat serving as the recipient. After eight backcross-intercross cycles (16 generations) the R\/APfd-j\/j strain was obtained which is congenic with the R\/APfd strain. Congenicity was demonstrated by various techniques including transplantation of skin tissue, strain-specific tumour cells and hepatocytes, the mixed lymphocyte reaction, and comparison of biochemical markers. The potential of the novel inbred strain of jaundiced rat, R\/APfd-j\/j, and the corresponding control strain R\/APfd for biochemical and clinical studies of bilirubin metabolism are briefly discussed. <\/jats:p>","DOI":"10.1258\/002367786780808758","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T23:31:27Z","timestamp":1180395087000},"page":"335-342","source":"Crossref","is-referenced-by-count":11,"title":["The congenic normal R\/APfd and jaundiced R\/APfd-j\/j rat strains: a new animal model of hereditary non-haemolytic unconjugated hyperbilirubinaemia due to defective bilirubin conjugation"],"prefix":"10.1177","volume":"20","author":[{"given":"R.","family":"Leyten","sequence":"first","affiliation":[{"name":"Proefdierencentrum, Catholic University of Leuven, B-3030 Heverlee, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P. A. M.","family":"Vroemen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Annadal Hospital, University of Limburg, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Blanckaert","sequence":"additional","affiliation":[{"name":"Laboratory of Hepatology, Department of Medical Research, Campus Gasthuisberg, Catholic University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P. M.","family":"Heirwegh","sequence":"additional","affiliation":[{"name":"Laboratory of Hepatology, Department of Medical Research, Campus Gasthuisberg, Catholic University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,10,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367786780808758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367786780808758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T07:53:47Z","timestamp":1740902027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367786780808758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,10,1]]}},"alternative-id":["10.1258\/002367786780808758"],"URL":"https:\/\/doi.org\/10.1258\/002367786780808758","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"type":"print","value":"0023-6772"},{"type":"electronic","value":"1758-1117"}],"subject":[],"published":{"date-parts":[[1986,10,1]]}}}