{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:17:46Z","timestamp":1766135866555,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1986,7,1]],"date-time":"1986-07-01T00:00:00Z","timestamp":520560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1986,7,1]]},"abstract":"<jats:p> To examine the connection between caecal size and urea concentration in the caecal contents urease inhibition was tested in conventional animals and urea and urease were administered to germ-free rats and mice. Administration of alloxan and barbituric acid and immunization with urease led to slightly larger caeca in conventional animals. Neomycin treatment caused a clear enlargement of the caecum. In germ-free animals urease administration led to a reduction in the caecal size, whereas urea in the drinking water caused enlargement. The urea concentration and the urease activity in the caecal contents correlated well with the caecal weights. <\/jats:p>","DOI":"10.1258\/002367786780865665","type":"journal-article","created":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T23:49:29Z","timestamp":1184024969000},"page":"238-241","source":"Crossref","is-referenced-by-count":11,"title":["Intestinal accumulation of urea in germ-free animals - a factor in caecal enlargement"],"prefix":"10.1177","volume":"20","author":[{"given":"N.-C.","family":"Juhr","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Versuchstierkunde und Versuchstierkrankheiten der Freien Universit\u00e1t Berlin, Krahmerstrasse 6, 1000 Berlin 45, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ladeburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,7,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367786780865665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367786780865665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T14:10:15Z","timestamp":1740838215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367786780865665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,7,1]]}},"alternative-id":["10.1258\/002367786780865665"],"URL":"https:\/\/doi.org\/10.1258\/002367786780865665","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"type":"print","value":"0023-6772"},{"type":"electronic","value":"1758-1117"}],"subject":[],"published":{"date-parts":[[1986,7,1]]}}}