{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:38:39Z","timestamp":1792640319343,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:p> The reversal of the neuroleptanalagesic combination of fentanyl\/fluanisone using mixed agonist\/antagonist opioids has been investigated in the rabbit. All of the compounds studied (naloxone, nalbuphine, meptazinol, butorphanol, buprenorphine, pentazocine, doxapram) reversed the respiratory depression and sedation produced by fentanyl\/fluanisone. Fentanyl\/fluanisone produced profound analgesia for 180 min, which was rapidly and completely antagonized by naloxone. The mixed agonist\/antagonist opioids produced a reduction in the degree of analgesia but, in contrast to naloxone, analgesic activity persisted from 120 min (meptazinol) to 420 min (buprenorphine). Administration of buprenorphine to rabbits anaesthetized with fentanyl\/fluanisone and midazolam confirmed that the reversal of respiratory depression was accompanied by the return of arterial pH, PCO<jats:sub>2<\/jats:sub> and PCO<jats:sub>2<\/jats:sub> to pre-anaesthetic values. <\/jats:p><jats:p> The use of neuroleptanalgesic anaesthetic regimens, which have been shown to provide effective surgical anaesthesia, combined with reversal using a mixed agonist\/antagonist opioid to provide postoperative analgesia, appears to be a valuable refinement of current laboratory animal anaesthetic practice. <\/jats:p>","DOI":"10.1258\/002367789780863655","type":"journal-article","created":{"date-parts":[[2007,6,3]],"date-time":"2007-06-03T23:37:51Z","timestamp":1180913871000},"page":"147-155","source":"Crossref","is-referenced-by-count":52,"title":["Reversal of fentanyl\/fluanisone neuroleptanalgesia in the rabbit using mixed agonist\/antagonist opioids"],"prefix":"10.1177","volume":"23","author":[{"given":"P. A.","family":"Flecknell","sequence":"first","affiliation":[{"name":"Comparative Biology Centre, Medical School, Framlington Place, Newcastle upon Tyne, Tyne and Wear, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Liles","sequence":"additional","affiliation":[{"name":"Comparative Biology Centre, Medical School, Framlington Place, Newcastle upon Tyne, Tyne and Wear, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wootton","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1989,4,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367789780863655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367789780863655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T22:38:15Z","timestamp":1741041495000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367789780863655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,4,1]]}},"alternative-id":["10.1258\/002367789780863655"],"URL":"https:\/\/doi.org\/10.1258\/002367789780863655","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}