{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:54:47Z","timestamp":1767664487685,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1992,10,1]]},"abstract":"<jats:p> In a 2 year carcinogenicity bioassay using B6C3F1 mice, one male mouse developed clinical signs near termination of the study, comprising skin sores around the prepuce, penile prolapse and urine scalding. The predominant finding at necropsy was a markedly distended urinary bladder filled with numerous crystallized particles. Microscopically, there was subacute cystitis with marked hyperplasia of the transitional epithelium. X-ray diffraction analysis of the crystals showed a diffraction pattern characteristic of struvite (ammonium magnesium phosphate). The implications of the spontaneous occurrence of bladder stones in rodents on long-term toxicology studies are discussed. <\/jats:p>","DOI":"10.1258\/002367792780745742","type":"journal-article","created":{"date-parts":[[2007,5,20]],"date-time":"2007-05-20T23:45:00Z","timestamp":1179704700000},"page":"281-287","source":"Crossref","is-referenced-by-count":4,"title":["Struvite urolithiasis in a B6C3F1 mouse"],"prefix":"10.1177","volume":"26","author":[{"given":"Z. W.","family":"Wojcinski","sequence":"first","affiliation":[{"name":"Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, L5K 1B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Renlund","sequence":"additional","affiliation":[{"name":"Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, L5K 1B4, Canada; Division of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Barsoum","sequence":"additional","affiliation":[{"name":"Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, L5K 1B4, Canada; Womens College Hospital, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, L5K 1B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,10,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367792780745742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367792780745742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T10:32:35Z","timestamp":1740997955000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367792780745742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10,1]]}},"alternative-id":["10.1258\/002367792780745742"],"URL":"https:\/\/doi.org\/10.1258\/002367792780745742","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"type":"print","value":"0023-6772"},{"type":"electronic","value":"1758-1117"}],"subject":[],"published":{"date-parts":[[1992,10,1]]}}}