{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:17:50Z","timestamp":1777439870973,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1993,7,1]]},"abstract":"<jats:p> Prolonged, stable, non-recovery anaesthesia is required for the assessment of the effects of novel compounds on the cardiovascular system. A comparison of injectable anaesthetic agents and combinations (thiobarbital, fentanyl-fluanisone and midazolam, propofol, fentanyl-fluanisone and propofol, and alphaxalone\/alphadolone) was made in laboratory rats and the following parameters assessed over 3 h: blood pressure, heart rate and rhythm, respiration rate and depth, analgesia, ease of induction and maintenance of anaesthesia. It was found that propofol, with fentanyl-fluanisone premedication, provided stress-free induction, easily controlled anaesthesia, good analgesia and muscle relaxation for surgery, for up to 3 h duration. Heart rate, blood pressure and respiration remained stable and within normal limits during this time. The other anaesthetics\/combinations assessed did not rate as highly in these respects. Propofol, following fentanyl-fluanisone premedication, would appear to be a useful and safe anaesthetic for use in rodents, which avoids significant effects on heart rate or blood pressure. <\/jats:p>","DOI":"10.1258\/002367793780745354","type":"journal-article","created":{"date-parts":[[2007,5,20]],"date-time":"2007-05-20T23:45:00Z","timestamp":1179704700000},"page":"250-257","source":"Crossref","is-referenced-by-count":44,"title":["A comparison of propofol with other injectable anaesthetics in a rat model for measuring cardiovascular parameters"],"prefix":"10.1177","volume":"27","author":[{"given":"A.","family":"Brammer","sequence":"first","affiliation":[{"name":"Zeneca Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire SK10 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"West","sequence":"additional","affiliation":[{"name":"Zeneca Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire SK10 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Zeneca Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, Cheshire SK10 4TJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,7,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367793780745354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367793780745354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T13:16:49Z","timestamp":1740835009000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367793780745354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7,1]]}},"alternative-id":["10.1258\/002367793780745354"],"URL":"https:\/\/doi.org\/10.1258\/002367793780745354","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7,1]]}}}