{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:14:50Z","timestamp":1784888090504,"version":"3.55.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:p> The results of a preliminary evaluation of etorphine\/methotrimeprazine ('Small Animal Immobilon') and midazolam in rats and mice are reported, and this regimen is compared to fentanyl\/fluanisone\/midazolam in mice. In rats, a surgical plane of anaesthesia with good muscle relaxation was produced, but blood gas analysis showed the presence of severe hypoxia, hypercapnia and acidosis. In mice etorphine\/methotrimeprazine\/midazolam and fentanyl\/fluanisone\/midazolam produced adequate anaesthesia, but blood gas analysis showed severe respiratory depression with both regimens. Since etorphine\/methotrimeprazine\/midazolam produced severe respiratory depression in rats and mice it is suggested that this regimen is used with caution. Administration of supplemental oxygen would seem advisable when using either etorphine\/methotrimeprazine\/midazolam or fentanyl\/fluanisone\/midazolam in rats and mice. <\/jats:p>","DOI":"10.1258\/002367794781065735","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T17:40:33Z","timestamp":1183225233000},"page":"70-77","source":"Crossref","is-referenced-by-count":14,"title":["The use of etorphine\/methotrimeprazine and midazolam as an anaesthetic technique in laboratory rats and mice"],"prefix":"10.1177","volume":"28","author":[{"given":"G.","family":"Whelan","sequence":"first","affiliation":[{"name":"Comparative Biology Centre, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Flecknell","sequence":"additional","affiliation":[{"name":"Comparative Biology Centre, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,1,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367794781065735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367794781065735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:39:00Z","timestamp":1740994740000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367794781065735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1,1]]}},"alternative-id":["10.1258\/002367794781065735"],"URL":"https:\/\/doi.org\/10.1258\/002367794781065735","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1,1]]}}}