{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:57:39Z","timestamp":1790855859144,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:p> Rats received pentobarbitone (60, 48 and 36 mg\/kg i.p.) or ketamine\/medetomidine (75\/100, 60\/80 and 45\/60 mg\/\u03bcg\/kg i.p.) alone, or one hour following buprenorphine (0.5 mg\/kg s.c.). Animals were anaesthetized once per week for 6 weeks with one of three anaesthetic doses according to a randomized block design. In the pentobarbitone group, animals which received buprenorphine had longer sleep times (236 \u00b1 22 cf. 204 \u00b1 21 min) and longer durations of surgical anaesthesia (83 \u00b1 14 cf. 27 \u00b1 8 min) ( P &lt;0.01), these effects being potentiated with increasing anaesthetic doses ( P &lt;0.01). A greater degree of respiratory depression was found in animals that received buprenorphine ( P &lt;0.01) although this was judged clinically acceptable in all cases. Unexpectedly high mortality and a high incidence of anaesthetic complications (nine of 16 animals) in the ketamine\/medetomidine group made statistical analysis of these data impossible. We conclude that for pentobarbitone, pre-anaesthetic administration of buprenorphine reduces the dose of anaesthetic required to produce surgical anaesthesia, in addition to the presumed benefits of pre-emptive analgesia. In view of the high mortality encountered, we advise caution when considering pre-anaesthetic use of opioids in combination with ketamine\/medetomidine in rats. <\/jats:p>","DOI":"10.1258\/002367799780578183","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T23:40:53Z","timestamp":1177630853000},"page":"234-242","source":"Crossref","is-referenced-by-count":27,"title":["The influence of pre-anaesthetic administration of buprenorphine on the anaesthetic effects of ketamine\/medetomidine and pentobarbitone in rats and the consequences of repeated anaesthesia"],"prefix":"10.1177","volume":"33","author":[{"given":"J. V.","family":"Roughan","sequence":"first","affiliation":[{"name":"Comparative Biology Centre, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Burzaco","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Surgical Teaching Hospital, Faculty of Veterinary Medicine, University of Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Flecknell","sequence":"additional","affiliation":[{"name":"Comparative Biology Centre, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,7,1]]},"container-title":["Laboratory Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367799780578183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/002367799780578183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:38:53Z","timestamp":1740994733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/002367799780578183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,7,1]]}},"alternative-id":["10.1258\/002367799780578183"],"URL":"https:\/\/doi.org\/10.1258\/002367799780578183","relation":{},"ISSN":["0023-6772","1758-1117"],"issn-type":[{"value":"0023-6772","type":"print"},{"value":"1758-1117","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}