{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:50:24Z","timestamp":1789775424178,"version":"4.0.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:p> Our objectives were to determine the prevalence of Neisseria gonorrhoeae not fully sensitive to ciprofloxacin from a sexually transmitted infection (STI) clinic in London and where the isolates were acquired from. Data of antibiotic sensitivities of N. gonorrhoeae from 292 patients were reviewed over a 6-month period at St Mary's Genitourinary Medicine (GUM) Clinic, London. Isolates which exhibited reduced susceptibility (minimum inhibitory concentration [MIC] 0.03-0.12 mg\/l) and high level resistance (MIC&gt;0.12 mg\/l) to ciprofloxacin represented 10% and 1.3% of the total respectively. All patients infected with a high level resistant isolate to ciprofloxacin had had a recent sexual partner from abroad but 18 of the 28 patients infected with a reduced susceptibility isolate denied recent travel. None of the 20 patients with a non-sensitive isolate who re-attended for post treatment cultures had persistant gonococcal infection. From this study we concluded that although N. gonorrhoeae resistant to ciprofloxacin was rare and probably always acquired abroad, isolates exhibiting reduced susceptibility were more common and were mainly as a result of infection from the UK. A stat dose of ciprofloxacin 500 mg and doxycycline 100 mg twice a day for one week was effective treatment. <\/jats:p>","DOI":"10.1258\/0956462001915264","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T09:48:30Z","timestamp":1034761710000},"page":"774-776","source":"Crossref","is-referenced-by-count":12,"title":["<i>Neisseria gonorrhoeae<\/i> in a London sexually transmitted infection                clinic not fully sensitive to quinolones: are isolates imported and how effective is                ciprofloxacin as a first-line therapy?"],"prefix":"10.1177","volume":"11","author":[{"given":"D","family":"Ivens","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Jefferiss Wing, Imperial College\r                  School of Medicine, St Mary's Hospital, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Imperial College\r                  School of Medicine, Norfolk Place W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ison","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology, Imperial College\r                  School of Medicine, Norfolk Place W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,12,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462001915264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462001915264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T08:44:02Z","timestamp":1740905042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462001915264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12,1]]}},"alternative-id":["10.1258\/0956462001915264"],"URL":"https:\/\/doi.org\/10.1258\/0956462001915264","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,1]]}}}