{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:07:19Z","timestamp":1759990039528,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:p> Varicella zoster virus (VZV) is an uncommon but well recognized cause of neurological disease in HIV-infected patients. Analysis of cerebrospinal fluid (CSF) using the polymerase chain reaction (PCR) in HIV-infected patients presenting with neurological disease has increasingly allowed diagnosis of VZV-associated pathology. We report clinical, radiological and virological data from 15 consecutive patients with VZV-associated neurological disease. Clinical presentation was varied, including meningo-encephalitis in 9 and isolated cranial nerve palsies in 6. VZV deoxyribonucleic acid (DNA) was detected by PCR in CSF of 11\/15; pleocytosis was present in only 6\/15, raised protein in 11\/15. Magnetic resonance imaging (MRI) appearances were focal signal abnormalities in 8, meningeal enhancement in 2 and normal in 2. With specific anti-VZV therapy 10 patients recovered fully. The predictive value of PCR on CSF for diagnosis of VZV-associated neurological disease should take into account the patient's clinical presentation, concurrent infections and response to anti-VZV therapy. <\/jats:p>","DOI":"10.1258\/0956462011916820","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T09:48:30Z","timestamp":1034761710000},"page":"79-83","source":"Crossref","is-referenced-by-count":12,"title":["Varicella zoster virus-associated neurological disease in HIV-infected                patients"],"prefix":"10.1177","volume":"12","author":[{"given":"M.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Camden & Islington Community Health Services NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scarborough","sequence":"additional","affiliation":[{"name":"Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Camden & Islington Community Health Services NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Virology, University College London Hospitals NHS Trust,\r                  London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Manji","sequence":"additional","affiliation":[{"name":"Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Camden & Islington Community Health Services NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Camden & Islington Community Health Services NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,2,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462011916820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462011916820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T19:22:26Z","timestamp":1740943346000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462011916820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2,1]]}},"alternative-id":["10.1258\/0956462011916820"],"URL":"https:\/\/doi.org\/10.1258\/0956462011916820","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}