{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:51:31Z","timestamp":1759402291442,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:p> Early identification of infants perinatally infected with HIV (HIV+) requires costly laboratory tests which are not widely available in countries with limited resources. We evaluated the utility of detection of non-specific HIV-related signs and symptoms and immunological abnormalities in the diagnosis of perinatal HIV infection in Brazilian infants younger than 10 months of age and followed from birth. A total of 27 HIV+ and 43 uninfected infants were studied. All infants exhibited one or more non-specific HIV-related findings at least once. HIV+ infants were more frequently symptomatic than HIV- infants only when older than 3 months. Combinations of clinical and immunological findings resulted in high sensitivity (85-100%) and low specificity (25-65%) rates for the diagnosis of HIV infection. Conversely, low CD4+ cell counts and hyperimmunoglobulinaemia showed low sensitivity (52%) and high specificity (100%) rates. In conclusion, the detection of similar findings in HIV- and HIV+ infants underscores the need of early confirmatory laboratory testing. <\/jats:p>","DOI":"10.1258\/0956462011916901","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T09:48:30Z","timestamp":1034761710000},"page":"197-203","source":"Crossref","is-referenced-by-count":2,"title":["Predicting perinatal HIV infection in young Brazilian infants: how                accurate are signs, symptoms and immunological abnormalities?"],"prefix":"10.1177","volume":"12","author":[{"given":"M. M.","family":"Mussi-Pinhata","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine of Ribeir\u00e3o Preto,\r                  University of S\u00e3o Paulo, Campus USP, 14049 900 Ribeir\u00e3o Preto, S\u00e3o Paulo,\r                  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Cervi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine of Ribeir\u00e3o Preto,\r                  University of S\u00e3o Paulo, Campus USP, 14049 900 Ribeir\u00e3o Preto, S\u00e3o Paulo,\r                  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Isaac","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine of Ribeir\u00e3o Preto,\r                  University of S\u00e3o Paulo, Campus USP, 14049 900 Ribeir\u00e3o Preto, S\u00e3o Paulo,\r                  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,3,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462011916901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462011916901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T03:35:48Z","timestamp":1740972948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462011916901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3,1]]}},"alternative-id":["10.1258\/0956462011916901"],"URL":"https:\/\/doi.org\/10.1258\/0956462011916901","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2001,3,1]]}}}