{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:41:14Z","timestamp":1741153274455,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p> We examined the hypothesis that the sac-4 gene of Neisseria gonorrhoeae varies with gonococcal subtype and that this could account for an earlier report that sac-4 increased the likelihood of co-infection with Chlamydia trachomatis. A polymerase chain reaction (PCR) assay was used to determine the prevalence of sac-4 in 435 gonococcal isolates. The prevalence of sac-4 was analysed in relation to chlamydial co-infection, serovar, auxotype, gender and sexual orientation. Although the prevalence of sac-4 was higher in isolates from patients with chlamydial co-infection (55%) than in those without chlamydial co-infection (42%) the difference was not significant ( P&lt;0.05). Statistically significant differences in association with sac-4 were, however, shown between various serovars and auxotypes. Dual classification based on auxotype\/serovar (A\/S) classes showed highly significant differences in sac-4 prevalence between groups: 95% in NR\/1B18 and 8% in P\/1B2 ( P&lt;0.001). Sac-4 was also significantly less common ( P&lt;0.05) in isolates from homosexual men (35%) than from heterosexual men (49%) or women (49.5%). Sac-4 appears to have an epidemiological association with gonococcal auxotype and serovar rather than a direct association with chlamydial co-infection. <\/jats:p>","DOI":"10.1258\/0956462021924866","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T09:48:30Z","timestamp":1034761710000},"page":"174-177","source":"Crossref","is-referenced-by-count":1,"title":["The <i>sac-4<\/i> gene of <i>Neisseria gonorrhoeae<\/i>                correlates with gonococcal subtype not co-existing chlamydial                infection"],"prefix":"10.1177","volume":"13","author":[{"given":"S","family":"Gretton","sequence":"first","affiliation":[{"name":"Scottish Neisseria gonorrhoeae Reference Laboratory, Department of\r                  Medical Microbiology, Edinburgh University Medical School, Teviot Place, Edinburgh\r                  EH8 9AG, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Patrizio","sequence":"additional","affiliation":[{"name":"Scottish Neisseria gonorrhoeae Reference Laboratory, Department of\r                  Medical Microbiology, Edinburgh University Medical School, Teviot Place, Edinburgh\r                  EH8 9AG, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Young","sequence":"additional","affiliation":[{"name":"Scottish Neisseria gonorrhoeae Reference Laboratory, Department of\r                  Medical Microbiology, Edinburgh University Medical School, Teviot Place, Edinburgh\r                  EH8 9AG, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462021924866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462021924866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:27:39Z","timestamp":1741105659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462021924866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["10.1258\/0956462021924866"],"URL":"https:\/\/doi.org\/10.1258\/0956462021924866","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}