{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:14:52Z","timestamp":1743264892628,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:p> We examined the risk and determinants of developing severe liver toxicity in 108 HIV-infected patients showing adherence to nevirapine- and efavirenz-containing regimens. Between January 1997 and December 2000, 70 patients were treated with nevirapine- and 38 patients with efavirenz-containing regimens, for a median period of 127 days (interquartile range 65-240). Severe liver toxicity was defined as grade 3-4 elevations (&gt;5\u00d7upper limit of normal) of aminotransferases AST or ALT. A total of 22 (20%) patients showed severe liver toxicity, 17 of them were treated with nevirapine- and five with efavirenz-containing regimens (relative risk [RR]: 1.85, 95% confidence intervals [CIs] 0.74-4.61; P=not significant). Multivariate analysis showed the association of severe liver toxicity with hepatitis C antibody positive (RR 7.64; 95% CI: 1.48-39.52; P=0.01), nevirapine- or efavirenz-containing regimens combined with a protease inhibitor (RR: 3.07, 95% CI: 1.01-9.32, P=0.04) and alcohol intake greater than 40 g per day (RR: 3.09, 95% CI: 1.27-7.54, P=0.01). These findings have potential implications for selecting and monitoring antiretroviral therapy in HIV-infected patients with hepatitis C virus coinfection and for avoiding alcohol intake during antiretroviral therapy. <\/jats:p>","DOI":"10.1258\/09564620360719840","type":"journal-article","created":{"date-parts":[[2003,10,21]],"date-time":"2003-10-21T19:53:17Z","timestamp":1066765997000},"page":"776-781","source":"Crossref","is-referenced-by-count":32,"title":["Risk and determinants of developing severe liver toxicity during therapy with nevirapine-and efavirenz-containing regimens in HIV-infected patients"],"prefix":"10.1177","volume":"14","author":[{"given":"Javier","family":"Ena","sequence":"first","affiliation":[{"name":"HIV Unit, Internal Medicine Department, Marina Baixa Hospital, Partida de Galand\u00fa, 5, Villajoyosa, 03570 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Amador","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department, Marina Baixa Hospital, Partida de Galand\u00fa, 5, Villajoyosa, 03570 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Benito","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department, Marina Baixa Hospital, Partida de Galand\u00fa, 5, Villajoyosa, 03570 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicenta","family":"Fenoll","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department, Marina Baixa Hospital, Partida de Galand\u00fa, 5, Villajoyosa, 03570 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Pasquau","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department, Marina Baixa Hospital, Partida de Galand\u00fa, 5, Villajoyosa, 03570 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,11,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/09564620360719840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/09564620360719840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T14:08:13Z","timestamp":1740838093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/09564620360719840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2003,11,1]]}},"alternative-id":["10.1258\/09564620360719840"],"URL":"https:\/\/doi.org\/10.1258\/09564620360719840","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2003,11,1]]}}}