{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:48:47Z","timestamp":1738129727683,"version":"3.33.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:p> In order to evaluate the occurrence of hepatotoxicity in patients treated with antiretroviral therapy (ART) who switch protease inhibitor (PI), and the role of viral hepatitis in its development, we performed a retrospective study on 182 HIV patients treated with ART for 24 months. The presence of hepatitis viruses and alanine transaminase levels were evaluated. Hepatotoxicity developed in a low number of subjects without co-infection, but was significantly higher in co-infected patients (14\/51 versus 62\/131, P = 0.01). Ritonavir was associated with higher rates of severe hepatotoxicity in the co-infected group. Patients presenting any problems related to ART, including the development of hepatotoxicity, continued therapy by switching PI. The occurrence of hepatotoxicity with second\/third choice PIs, including ritonavir, remained stable. Our results suggest that switching PI does not increase the occurrence of drug-related liver toxicity. <\/jats:p>","DOI":"10.1258\/0956462053057585","type":"journal-article","created":{"date-parts":[[2005,2,12]],"date-time":"2005-02-12T06:12:15Z","timestamp":1108188735000},"page":"148-152","source":"Crossref","is-referenced-by-count":4,"title":["Development of hepatotoxicity in HIV patients switching at least one protease inhibitor"],"prefix":"10.1177","volume":"16","author":[{"given":"Antonio","family":"Aceti","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Sant'Andrea Hospital, II Faculty of Medicine, University of Rome 'La Sapienza', Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Pasquazzi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sant'Andrea Hospital, II Faculty of Medicine, University of Rome 'La Sapienza', Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Zechini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sant'Andrea Hospital, II Faculty of Medicine, University of Rome 'La Sapienza', Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"De Bac","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Sant'Andrea Hospital, II Faculty of Medicine, University of Rome 'La Sapienza', Via di Grottarossa 1035, 00189 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The LIVERHAART Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,2,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462053057585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462053057585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T18:09:06Z","timestamp":1738087746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462053057585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["10.1258\/0956462053057585"],"URL":"https:\/\/doi.org\/10.1258\/0956462053057585","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2005,2,1]]}}}