{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:05Z","timestamp":1761058265586,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:p> We have conducted a retrospective study of treatment failure of Trichomonas vaginalis (TV) infection in a busy, urban genitourinary medicine clinic in Birmingham, UK, between 1998 and 2002. The prevalence of non-response to standard doses of metronidazole without any history of reinfection or nonadherence was 1.7% (28\/1603) overall, and has significantly increased from 0.38% in 1999 to 3.5% in 2002 ( P=0.001, \u03c7<jats:sup>2<\/jats:sup> test). There were no associated demographic factors. The majority of patients (53% or 15\/28) responded to either a repeat of standard (10\/26) or higher oral dose (5\/7) of metronidazole. A standardized treatment algorithm using a high dose of metronidazole may be useful in the absence of any new, efficacious non-imidazole-based TV therapy in the clinical management of persistent TV infection. <\/jats:p>","DOI":"10.1258\/0956462053654258","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T06:28:44Z","timestamp":1114064924000},"page":"284-286","source":"Crossref","is-referenced-by-count":21,"title":["Treatment failure of vaginal trichomoniasis in clinical practice"],"prefix":"10.1177","volume":"16","author":[{"given":"Satyajit","family":"Das","sequence":"first","affiliation":[{"name":"Department of Genito-Urinary Medicine, Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Huengsberg","sequence":"additional","affiliation":[{"name":"Department of Genito-Urinary Medicine, Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Shahmanesh","sequence":"additional","affiliation":[{"name":"Department of Genito-Urinary Medicine, Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,4,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462053654258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462053654258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:10:44Z","timestamp":1741108244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462053654258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4,1]]}},"alternative-id":["10.1258\/0956462053654258"],"URL":"https:\/\/doi.org\/10.1258\/0956462053654258","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"type":"print","value":"0956-4624"},{"type":"electronic","value":"1758-1052"}],"subject":[],"published":{"date-parts":[[2005,4,1]]}}}