{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:22:25Z","timestamp":1774426945199,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:p> Zidovudine (ZDV) has been associated with 'ragged-red' fibre myopathy, due to its effects on myocyte mitochondria. Usually this is reversible with cessation of ZDV. We report a 52-year-old man, who in 1985 developed ragged-red fibre myopathy 14 years after diagnosis of HIV infection while on effective ZDV-based combination antiretroviral therapy (ART). He was treated with the mitochondrial anti-oxidant coenzyme Q<jats:sub>10<\/jats:sub> and made an excellent recovery, without change of ARTs. This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV. <\/jats:p>","DOI":"10.1258\/095646205774988127","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T22:51:28Z","timestamp":1133477488000},"page":"827-829","source":"Crossref","is-referenced-by-count":9,"title":["Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q<sub>10<\/sub> therapy"],"prefix":"10.1177","volume":"16","author":[{"given":"Franklin L","family":"Rosenfeldt","sequence":"first","affiliation":[{"name":"Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Mijch","sequence":"additional","affiliation":[{"name":"HIV Service, Department of Infectious Diseases, The Alfred Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"McCrystal","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Pepe","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Cardiac Surgical Research Unit, Alfred Hospital & Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"Dennett","sequence":"additional","affiliation":[{"name":"State Neuropathology Service, Department of Pathology, University of Melbourne, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/095646205774988127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/095646205774988127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T20:25:34Z","timestamp":1741033534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/095646205774988127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12,1]]}},"alternative-id":["10.1258\/095646205774988127"],"URL":"https:\/\/doi.org\/10.1258\/095646205774988127","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,1]]}}}