{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:45:52Z","timestamp":1772084752299,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p> Hepatitis C virus (HCV) and hepatitis B virus (HBV) co-infection may differentially influence HIV treatment duration and outcome. This was assessed at The Ottawa Hospital Immunodeficiency Clinic in first-time highly active antiretroviral therapy (HAART) recipients visited between January 2000 and December 2004. Of 968 patients, 526\/700 (75%) HIV, 173\/230 (75%) HIV\u2013HCV and 30\/38 (79%) HIV\u2013HBV-infected patients initiated HAART. Co-infected patients stopped treatment sooner (HBV \u2013 10 months, HCV \u2013 9 months) than HIV mono-infected (17 months) ( P&lt;0.001). Injection drug history predicted shorter treatment duration (odds ratio [OR]1.59, P&lt;0.001). Use of non-nucleoside-reverse-transcriptase-inhibitor-containing HAART (OR 0.76, P&lt;0.01) and low-dose ritonavir (&lt;400 mg twice daily)-based HAART (OR 0.83, P = 0.06) predicted longer treatment duration. HCV co-infection did not predict duration of therapy (OR 1.19, P=0.19) once controlled for by these three variables. Poor adherence was a major explanation for eventual treatment interruption in those with HIV\u2013HCV (22% versus 5% in HIV alone; P&lt;0.001) as was substance abuse (7% versus &lt; 1% in HIV; P&lt;0.001). Metabolic complications resulted in HAART interruption in HIV mono-infection (8%) but not with HBV or HCV co-infection (both &lt;1%; P&lt;0.001). Antiretroviral selection is critical to the longevity of initially prescribed regimens, irrespective of viral hepatitis co-infection. Attention to this and strategies targeting substance abuse and adherence in HIV\u2013HCV are predicted to increase the duration of HAART. <\/jats:p>","DOI":"10.1258\/095646207781439838","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T23:33:55Z","timestamp":1186097635000},"page":"546-550","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of first antiretroviral treatment duration and outcome in HIV, HIV\u2013HBV and HIV\u2013HCV infection"],"prefix":"10.1177","volume":"18","author":[{"given":"Curtis L","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, Canada; Centre for International Health and Human Rights Studies, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Mills","sequence":"additional","affiliation":[{"name":"Centre for International Health and Human Rights Studies, Toronto, Canada; Department of Epidemiology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,8,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/095646207781439838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/095646207781439838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T19:37:45Z","timestamp":1740944265000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/095646207781439838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8,1]]}},"alternative-id":["10.1258\/095646207781439838"],"URL":"https:\/\/doi.org\/10.1258\/095646207781439838","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,1]]}}}