{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:05:07Z","timestamp":1789909507144,"version":"4.0.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:p> To assess the efficacy of a novel glycosylated mammalian cell derived recombinant human interferon- (r-hIFN--1a) in the intralesional treatment of genital condylomata acuminata. The study was randomized, double-blind and placebo-controlled. Patients ( n =60) with up to 8 distinct condylomata acuminata were randomized to receive either one million international units (IU) of r-hIFN--1a or placebo intralesionally into each lesion, 3 times a week, for a total of 9 occasions. Biopsies were taken from each patient before enrolment to allow human papillomavirus (HPV) testing, and patients were tested for the development of anti-IFN- antibodies. Efficacy was assessed by measuring the complete response rate 3 months after treatment. The complete response rate was not significantly better with r-hIFN--1a than with placebo. However, after 3 months, 73.3% of patients treated with r-hIFN--1a had experienced at least a partial response to treatment, compared with 33.3% of placebo-treated patients. At 19 days and 6 weeks, r-hIFN--1a produced a significantly larger reduction in the area of condylomata. Lesions with detectable HPV 6 or 11 showed a trend towards a better response rate to treatment with rhIFN--1a than lesions where no HPV DNA was detected. The treatment was well tolerated. In the 5 patients who developed non-neutralizing anti-IFN- antibodies, therapeutic efficacy was not compromised. Intralesional r-hIFN--1a was effective in the reduction of the size of genital condylomata acuminata. <\/jats:p>","DOI":"10.1258\/0956462971918878","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T10:10:33Z","timestamp":1034763033000},"page":"614-621","source":"Crossref","is-referenced-by-count":17,"title":["Recombinant human interferon- for condylomata acuminata: a randomized, double-blind, placebo-controlled study of intralesional therapy"],"prefix":"10.1177","volume":"8","author":[{"given":"Jacob","family":"Bornstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pascal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Zarfati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrod","family":"Goldschmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Abramovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,10,1]]},"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462971918878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0956462971918878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T22:53:27Z","timestamp":1740956007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0956462971918878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10,1]]}},"alternative-id":["10.1258\/0956462971918878"],"URL":"https:\/\/doi.org\/10.1258\/0956462971918878","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10,1]]}}}