{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:53:53Z","timestamp":1792536833699,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p> Streptococcus agalactiae, or Lancefield group B streptococcus (GBS), is the most frequent cause of serious bacterial sepsis, including neonatal meningitis, in UK neonates. Early-onset neonatal GBS infection, but not late-onset, can be prevented by screening to identify high-risk pregnancies and administering penicillin during delivery. A vaccine has been developed as an alternative means of prevention but it is awaiting a randomized trial before being available for general use. In this review we examine the published literature to assess the morbidity and mortality attributable to neonatal GBS infection, quantify the screening performance of the two alternative modes of screening (microbiological and risk factor based), review the evidence on the efficacy of the vaccine, and estimate the numbers of deaths and cases of serious disability that each strategy in turn might prevent in the UK, in order to assess the most effective means of prevention for the UK. <\/jats:p>","DOI":"10.1258\/0969141053908366","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T23:46:03Z","timestamp":1116459963000},"page":"60-68","source":"Crossref","is-referenced-by-count":41,"title":["The prevention of neonatal group B streptococcal disease: a report by a working group of the Medical Screening Society"],"prefix":"10.1177","volume":"12","author":[{"given":"MR","family":"Law","sequence":"first","affiliation":[{"name":"Chairman, Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1 M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Palomaki","sequence":"additional","affiliation":[{"name":"Rapporteur, Division of Medical Screening, Department of Pathology, Women and Infants Hospital, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Alfirevic","sequence":"additional","affiliation":[{"name":"Liverpool Women's Hospital, Crown Street, Liverpool L8 7SS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics, 30 Guildford Street, London WC1N IEH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Child Health, St George's Hospital Medical School, London SW17 0RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"McCartney","sequence":"additional","affiliation":[{"name":"Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Reid","sequence":"additional","affiliation":[{"name":"Dept of Medical Microbiology, Grampian University Hospitals Trust, Foresterhill, Aberdeen AB25 2ZN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Schrag","sequence":"additional","affiliation":[{"name":"Centers for Disease Control (CDC), Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,6,1]]},"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0969141053908366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/0969141053908366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T10:55:05Z","timestamp":1740999305000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/0969141053908366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6,1]]}},"alternative-id":["10.1258\/0969141053908366"],"URL":"https:\/\/doi.org\/10.1258\/0969141053908366","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}