{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:29:48Z","timestamp":1789349388881,"version":"build-2803163510"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Screen"],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:p> Objectives: To compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (HPV) types for the first time in a UK screening setting. <\/jats:p><jats:p> Setting: Nine hundred and twenty women, from two demographically different centres, attending for routine cervical smear testing <\/jats:p><jats:p> Methods: Women performed an unsupervised HPV self-test. Immediately afterwards, a doctor or nurse took an HPV test and cervical smear. Women with an abnormality on any test were offered colposcopy. <\/jats:p><jats:p> Results: Twenty-one high-grade and 39 low-grade cervical intraepithelial neoplasias (CINs) were detected. The sensitivity for high-grade disease (CIN2+) for the self HPV test was 81% (95% confidence interval [CI] 60\u201392), clinician HPV test 100% (95% CI 85\u2013100), cytology 81% (95% CI 60\u201392). The sensitivity of both HPV tests to detect high- and low-grade cervical neoplasia was much higher than that of cytology (self-test 77% [95%CI 65\u201386], clinician test 80% [95% CI 68\u201388], cytology 48% [95% CI 36\u201361]). For both high-grade alone, and high and low grades together, the specificity was significantly higher for cytology (greater than 95%) than either HPV test (between 82% and 87%). The self-test proved highly acceptable to women and they reported that the instructions were easy to understand irrespective of educational level. <\/jats:p><jats:p> Conclusions: Our results suggest that it would be reasonable to offer HPV self-testing to women who are reluctant to attend for cervical smears. This approach should now be directly evaluated among women who have been non-attenders in a cervical screening programme. <\/jats:p>","DOI":"10.1258\/096914107780154486","type":"journal-article","created":{"date-parts":[[2007,3,11]],"date-time":"2007-03-11T22:16:46Z","timestamp":1173651406000},"page":"34-42","source":"Crossref","is-referenced-by-count":66,"title":["Human papillomavirus testing by self-sampling: assessment of accuracy in               an unsupervised clinical setting"],"prefix":"10.1177","volume":"14","author":[{"given":"Anne","family":"Szarewski","sequence":"first","affiliation":[{"name":"Cancer Research UK Centre for Epidemiology, Mathematics and                  Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London                  EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cadman","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre for Epidemiology, Mathematics and                  Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London                  EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mallett","sequence":"additional","affiliation":[{"name":"Cancer Research UK Medical Statistics Group, Centre for Statistics in                  Medicine, Wolfson College, Linton Road, Oxford OX2 6UD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Austin","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre for Epidemiology, Mathematics and                  Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London                  EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Londesborough","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre for Epidemiology, Mathematics and                  Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London                  EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Waller","sequence":"additional","affiliation":[{"name":"Health Behaviour Unit, Cancer Research UK, Department of Epidemiology                  and Public Health, University College, London, 2\u201316 Torrington Place, London WC1E                  6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Wardle","sequence":"additional","affiliation":[{"name":"Health Behaviour Unit, Cancer Research UK, Department of Epidemiology                  and Public Health, University College, London, 2\u201316 Torrington Place, London WC1E                  6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G","family":"Altman","sequence":"additional","affiliation":[{"name":"Cancer Research UK Medical Statistics Group, Centre for Statistics in                  Medicine, Wolfson College, Linton Road, Oxford OX2 6UD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Cuzick","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre for Epidemiology, Mathematics and                  Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London                  EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,3,1]]},"container-title":["Journal of Medical Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/096914107780154486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/096914107780154486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T22:17:42Z","timestamp":1740953862000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/096914107780154486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3,1]]}},"alternative-id":["10.1258\/096914107780154486"],"URL":"https:\/\/doi.org\/10.1258\/096914107780154486","relation":{},"ISSN":["0969-1413","1475-5793"],"issn-type":[{"value":"0969-1413","type":"print"},{"value":"1475-5793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,1]]}}}