{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:54:17Z","timestamp":1777434857109,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>About 50% of kidney-transplant patients undergo organ rejection within 10 years. Chronic allograft nephropathy (CAN) represents the dominant cause of kidney transplant failure and accounts for 50\u201380% of graft loss in long-term surviving patients. CAN pathogenesis is multifactorial and not-completely elucidated; several reports indicate TGF-\u03b21 and platelet-derived growth factor (PDGF)-BB expression in CAN suggesting a possible role of these factors in the allograft arteriosclerosis and graft failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the plasma expression concentrations of human growth factors with enzyme-linked immunosorbent assays and appropriate statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We present evidences showing statistically significant association of CAN with a specific balance between TGF Beat1 and PDGF-BB plasma concentrations, in 129 kidney-transplant patients and 15 healthy controls. Odds ratios were computed to correlate expression-levels with CAN occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We believe these data may suggest a novel non-invasive method to identify early molecular markers of graft deterioration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2007.007155","type":"journal-article","created":{"date-parts":[[2008,3,2]],"date-time":"2008-03-02T19:31:35Z","timestamp":1204486295000},"page":"213-214","source":"Crossref","is-referenced-by-count":4,"title":["Balance of transforming growth factor-\u03b21 and platelet-derived growth factor-BB is associated with kidney allograft rejection"],"prefix":"10.1177","volume":"45","author":[{"given":"Ubaldo","family":"Pozzetto","sequence":"first","affiliation":[{"name":"Centro Shock, IASI\u2013CNR, Largo Gemelli 8, 00168 Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Abeni","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata, IDI-IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Citterio","sequence":"additional","affiliation":[{"name":"Dipartimento di Chirurgia, Universit\u00e0 Cattolica Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Castagneto","sequence":"additional","affiliation":[{"name":"Dipartimento di Chirurgia, Universit\u00e0 Cattolica Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio C","family":"Capogrossi","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata, IDI-IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Facchiano","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata, IDI-IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"bibr-ACB-07-155C1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2003.tb00277.x"},{"key":"bibr-ACB-07-155C2","first-page":"S295","volume":"13","author":"Mohamed MA","year":"2000","journal-title":"Transpl Int"},{"key":"bibr-ACB-07-155C3","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000062836.93496.CE"},{"key":"bibr-ACB-07-155C4","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000206102.67063.24"},{"key":"bibr-ACB-07-155C5","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000045056.82561.0F"},{"key":"bibr-ACB-07-155C6","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.4.561"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2007.007155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2007.007155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2007.007155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:54:58Z","timestamp":1777377298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2007.007155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1258\/acb.2007.007155"],"URL":"https:\/\/doi.org\/10.1258\/acb.2007.007155","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}