{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:42:07Z","timestamp":1792726927135,"version":"4.5.0"},"reference-count":5,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Finger-prick sampling is an alternative strategy for monitoring immunosuppressive drug concentrations that could be useful in reducing outpatient visits. We investigated the correlation between venous and finger-prick samples in a group of adult thoracic transplant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples ( n = 65) for the measurement of whole blood tacrolimus were collected from adult heart ( n = 18) and lung transplant ( n = 20) recipients receiving tacrolimus-based immunosuppressive therapy and a finger-prick sample was taken at the same time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between-batch assay imprecision (coefficient of variation [CV], %) for the last 12 months ( n = 270) at concentrations of 3.5, 6.9 and 13.9 \u03bcg\/L was 8.0%, 5.4% and 5.2%, respectively. Passing and Bablok regression analysis between finger-prick and venous blood showed finger-prick tacrolimus = 1.02 (venous blood tacrolimus) \u22120.06. Bland\u2013Altman analysis showed good agreement with a bias of 0.114 \u03bcg\/L and 95% limits of agreement from \u22121.0 to 1.2 \u03bcg\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The liquid chromatography mass spectrometry methodology that we have developed has the potential to allow patients or their carers to collect finger-prick blood samples at home and send them to the laboratory using the routine mail service. We believe that finger-prick blood sampling has an important role to play in the care of transplant patients receiving immunosuppressive drugs, including tacrolimus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2008.008147","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T10:17:55Z","timestamp":1234952275000},"page":"144-145","source":"Crossref","is-referenced-by-count":18,"title":["Liquid chromatography-mass spectrometry measurement of tacrolimus in finger-prick samples compared with venous whole blood samples"],"prefix":"10.1177","volume":"46","author":[{"given":"Brian G","family":"Keevil","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fildes","sequence":"additional","affiliation":[{"name":"Transplant Unit, Wythenshawe Hospital, Manchester, M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baynes","sequence":"additional","affiliation":[{"name":"Transplant Unit, Wythenshawe Hospital, Manchester, M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Yonan","sequence":"additional","affiliation":[{"name":"Transplant Unit, Wythenshawe Hospital, Manchester, M23 9LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,1,22]]},"reference":[{"key":"bibr-ACB-08-147C1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200212000-00013"},{"key":"bibr-ACB-08-147C2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0586-z"},{"key":"bibr-ACB-08-147C3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00472.x"},{"key":"bibr-ACB-08-147C4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00367.x"},{"key":"bibr-ACB-08-147C5","doi-asserted-by":"publisher","DOI":"10.1258\/000456302320314502"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2008.008147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2008.008147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2008.008147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:23Z","timestamp":1777377323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2008.008147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,22]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1258\/acb.2008.008147"],"URL":"https:\/\/doi.org\/10.1258\/acb.2008.008147","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,22]]}}}