{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:00:10Z","timestamp":1777435210128,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    Increased high-density lipoprotein (HDL)-cholesterol (hyperalphalipoproteinaemia; HALP) is commonly genetic, but may have secondary causes. An association between multiple lipomatosis and HALP has been reported; however, the mechanism for this is unclear. We report the case of a 69-year-old Cook Island woman with extreme HALP who presented with a large paraspinal lipoma. Magnetic resonance imaging showed no other lipomas. She had the metabolic syndrome, a family history suggestive of lipomas and was on lipid-lowering and antihypertensive therapy. Her plasma HDL-cholesterol concentration was 4.9 mmol\/L (&gt;95th percentile for age and sex) and was not explained by typical secondary causes. HDL\n                    <jats:sub>2<\/jats:sub>\n                    and HDL\n                    <jats:sub>3<\/jats:sub>\n                    subfractions were increased, with HDL\n                    <jats:sub>2<\/jats:sub>\n                    predominance. The excised lipoma histology demonstrated benign tissue and normal karyotype. Postoperative lipid profiles showed no change in HDL-cholesterol concentrations. In summary, we report a case of extreme HALP that persisted after excision of a solitary paraspinal lipoma.\n                  <\/jats:p>","DOI":"10.1258\/acb.2009.009168","type":"journal-article","created":{"date-parts":[[2009,11,26]],"date-time":"2009-11-26T00:08:17Z","timestamp":1259194097000},"page":"90-93","source":"Crossref","is-referenced-by-count":1,"title":["Extreme hyperalphalipoproteinaemia in a patient with a solitary paraspinal lipoma"],"prefix":"10.1177","volume":"47","author":[{"given":"Samarina","family":"Musaad","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J","family":"Hooper","sequence":"additional","affiliation":[{"name":"Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia"},{"name":"Schools of Medicine and Pharmacology and Pathology and Laboratory Medicine, University of Western Australia, Royal Perth Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"French","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weldon","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"Burnett","sequence":"additional","affiliation":[{"name":"Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia"},{"name":"Schools of Medicine and Pharmacology and Pathology and Laboratory Medicine, University of Western Australia, Royal Perth Hospital, Perth, 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