{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:40:27Z","timestamp":1784774427637,"version":"3.55.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T00:00:00Z","timestamp":1271203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA), the most common secondary cause of hypertension, can be screened for using the aldosterone\/renin ratio. This ratio is raised in PA and its accuracy depends on the ability to measure plasma renin at extremely low concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We compared two different procedures for assessing plasma renin. The conventional method, which measures plasma renin activity (PRA), is technically demanding and laborious, and the Diasorin Liaison\n                      <jats:sup>\u00ae<\/jats:sup>\n                      method, which measures plasma renin concentration (PRC), is an automated immunoassay. Results from each method were used to calculate the aldosterone\/renin ratio (ARR) and the performance of the Diasorin Liaison\n                      <jats:sup>\u00ae<\/jats:sup>\n                      method compared with that of the conventional assay using receiver operator characteristic curves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analytical and functional sensitivity of the PRC method were 2.1 and 5 \u03bcIU\/mL, respectively. Intra- and inter-assay precision were &lt;7.2% and 10.4%, respectively. There was significant (9%) prorenin interference. Samples with PRA &gt; 1.0 ng\/mL\/h showed significant correlation with PRC ( r = 0.93; P &lt; 0.05; n = 146); however, with PRA &lt; 1.0 ng\/mL\/h, no significant correlation occurred ( r = 0.14; P &lt; 0.05; n = 79). An aldosterone (pmol\/L)\/PRC(\u03bcIU\/mL) ratio of &gt;35, in patients with aldosterone &gt;300 pmol\/L, resulted in 100% sensitivity and 93% specificity, when compared with the commonly accepted aldosterone (pmol\/L)\/PRA (ng\/mL\/h) ratio of &gt;750, in identifying patients who may suffer from PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates the feasibility of using the automated PRC assay as a replacement for the conventional manual PRA assay in calculating the ARR as a first-line screen for PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2010.009230","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T20:40:33Z","timestamp":1271277633000},"page":"195-199","source":"Crossref","is-referenced-by-count":57,"title":["A screening procedure for primary aldosteronism based on the Diasorin Liaison\n                    <sup>\u00ae<\/sup>\n                    automated chemiluminescent immunoassay for direct renin"],"prefix":"10.1177","volume":"47","author":[{"given":"C A","family":"Dorrian","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Macewen Building, Royal Infirmary, Glasgow G4 0SF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Toole","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Macewen Building, Royal Infirmary, Glasgow G4 0SF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Alvarez-Madrazo","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow G12 8TA, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Macewen Building, Royal Infirmary, Glasgow G4 0SF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M C","family":"Connell","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow G12 8TA, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Macewen Building, Royal Infirmary, Glasgow G4 0SF"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"bibr-ACB-09-230C1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"bibr-ACB-09-230C2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032052"},{"key":"bibr-ACB-09-230C3","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033159"},{"key":"bibr-ACB-09-230C4","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.5.2.244"},{"key":"bibr-ACB-09-230C5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02971.x"},{"key":"bibr-ACB-09-230C6","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62105-8"},{"key":"bibr-ACB-09-230C7","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.118000"},{"key":"bibr-ACB-09-230C8","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.123042"},{"key":"bibr-ACB-09-230C9","first-page":"1213","volume":"10","author":"Derkx FHM","year":"1988","journal-title":"Clin Exp Hypertens"},{"key":"bibr-ACB-09-230C10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1406"},{"key":"bibr-ACB-09-230C11","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.27"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2010.009230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2010.009230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2010.009230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:54Z","timestamp":1777377354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2010.009230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,14]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1258\/acb.2010.009230"],"URL":"https:\/\/doi.org\/10.1258\/acb.2010.009230","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,14]]}}}