{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:05:51Z","timestamp":1777435551334,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:00:00Z","timestamp":1300752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperaldosteronism (PHA) is characterized by a raised plasma aldosterone concentration (PAC) with suppressed plasma renin activity (PRA). We evaluated two renin mass methods for PHA detection compared with the PAC:PRA ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Samples from patients attending a specialist hypertensive clinic were analysed by Liaison automated chemiluminescent immunoassay and Diagnostic Systems Laboratories (DSL) immunoradiometric assay (IRMA) for renin mass; I\n                      <jats:sup>\u2212125<\/jats:sup>\n                      radioimmunoassay of angiotensin I generated from endogenous angiotensinogen for PRA; Siemens Coat-a-count radioimmunoassay for PAC. Subjects included those on \u03b2-blockers which suppress renin, causing an equivalent biochemical picture to PHA. Aldosterone\/renin ratios (ARR) were calculated for PRA, DSL and Liaison methods. The first 100 subjects were used to identify cut-off ratios ensuring maximum specificity at 100% sensitivity for PHA detection. This cut-off was retested in a subsequent population ( n = 43).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A Liaison renin of 5 ng\/L separated PRAs of \u22640.5 from \u22650.6 pmol\/mL\/h. The DSL method had greater scatter. In population 1 (18 PHA), cut-off ratios of &gt;118 pmol\/ng (Liaison) and &gt;60 pmol\/ng (DSL) gave specificities of 58.5% and 61%, respectively, with 100% sensitivity. If criteria for PHA included PAC \u2265350 pmol\/L and excluded \u03b2-blocked subjects, specificity increased to 95.1% and 90% for Liaison and DSL, respectively. In population 2 (6 PHA), specificities for Liaison and DSL ARRs were 86.4% and 78.3%. Using the ratio with PAC and \u03b2-blocker criteria, specificities for Liaison and DSL were 97.3% and 86.5%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Liaison ARR used with PAC and \u03b2-blocker criteria provided an automatable alternative to identify the same patients as the PAC:PRA ratio.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2010.010171","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T22:48:02Z","timestamp":1300834082000},"page":"256-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity"],"prefix":"10.1177","volume":"48","author":[{"given":"Yehani N","family":"Wedatilake","sequence":"first","affiliation":[{"name":"Clinical Biochemistry, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike J","family":"Scanlon","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie C","family":"Barnes","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3,22]]},"reference":[{"key":"bibr-ACB-10-171C1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"bibr-ACB-10-171C2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1994.tb02519.x"},{"key":"bibr-ACB-10-171C3","first-page":"1863","volume":"85","author":"Fardella CE","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr-ACB-10-171C4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001013"},{"key":"bibr-ACB-10-171C5","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.07.007"},{"key":"bibr-ACB-10-171C6","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.33"},{"key":"bibr-ACB-10-171C7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340130033011"},{"key":"bibr-ACB-10-171C8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90178-3"},{"key":"bibr-ACB-10-171C9","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001899401"},{"key":"bibr-ACB-10-171C10","first-page":"27","volume":"13","author":"Sealey JE","year":"1995","journal-title":"J Hypertens"},{"key":"bibr-ACB-10-171C11","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033654"},{"key":"bibr-ACB-10-171C12","unstructured":"HolmesHC, ScanlonMJ, RogersA, KydP. Evaluation of the direct renin assay on Nichols Advantage. How well can it detect low and suppressed plasma renin activity?\n                      Proceedings of the National Meeting of the Association of Clinical Biochemistry\n                      , 2003:86"},{"key":"bibr-ACB-10-171C13","volume":"16","author":"Unger N","year":"2008","journal-title":"Eur Congr Endocrinol Endocr Abstr"},{"key":"bibr-ACB-10-171C14","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00005-9"},{"key":"bibr-ACB-10-171C15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01613.x"},{"key":"bibr-ACB-10-171C16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.01.013"},{"key":"bibr-ACB-10-171C17","first-page":"47","volume":"2","author":"Kyd P","year":"2000","journal-title":"CPD Bull Clin Biochem"},{"key":"bibr-ACB-10-171C18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X"},{"key":"bibr-ACB-10-171C19","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500517"},{"key":"bibr-ACB-10-171C20","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033159"},{"key":"bibr-ACB-10-171C21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00489.x"},{"key":"bibr-ACB-10-171C22","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.5-1-55"},{"key":"bibr-ACB-10-171C23","unstructured":"BidlingmaierM, KochzC, SchirpenbachC,  Screening for primary aldosteronism (PA): aldosterone to renin ratio (ARR) in healthy subjects, patients with essential hypertension and primary aldosteronism.\n                      Proceedings of German Society for Clinical Chemistry and Laboratory Medicine Annual Congress\n                      , 2007"},{"key":"bibr-ACB-10-171C24","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2010.009230"},{"key":"bibr-ACB-10-171C25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.006"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2010.010171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2010.010171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2010.010171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:56:20Z","timestamp":1777377380000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2010.010171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,22]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1258\/acb.2010.010171"],"URL":"https:\/\/doi.org\/10.1258\/acb.2010.010171","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,22]]}}}