{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:19:17Z","timestamp":1778087957748,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    A 50-year-old man presented with a four-year history of unsteadiness, with recent falls and tingling in his fingers. Neurological examination found an ataxic gait, with a positive Romberg's sign. There was distal wasting and weakness in all four limbs and impaired co-ordination, with pseudoathetosis in the arms. Initial investigations showed a normochromic, normocytic anaemia, leucopenia, neutropenia and a low vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    (172 ng\/L). Treatment with intramuscular cobalamin injections showed no clinical improvement. Further investigations showed an undetectable caeruloplasmin (&lt;0.085 g\/L), a very low serum copper (1.1 \u03bcmol\/L) and a markedly raised serum zinc concentration (36.2 \u03bcmol\/L). On detailed questioning it became apparent that he had ill-fitting dentures requiring excessive use of denture fixative with high zinc content. The patient was switched to a non-zinc containing denture fixative and commenced copper supplementation. Although within three months the bone marrow suppression had resolved, there was no clinical improvement in neurological presentation. Questioning a patient about their denture fixative usage and checking if zinc is an ingredient may be considered during an investigation for myelopolyneuropathy when vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency is not a cause.\n                  <\/jats:p>","DOI":"10.1258\/acb.2011.010282","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T21:09:05Z","timestamp":1303938545000},"page":"383-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Zinc poisoning from excessive denture fixative use masquerading as myelopolyneuropathy and hypocupraemia"],"prefix":"10.1177","volume":"48","author":[{"given":"A L","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G D P","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Cornwall Hospital, Truro, Cornwall, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"bibr-ACB-10-282C1","unstructured":"UK Consumer Advisory. Poligrip website. See http:\/\/www.poligrip.co.uk-consumer-advisory\/default.aspx (last checked 31st March, 2010)"},{"key":"bibr-ACB-10-282C2","first-page":"20","volume":"7","author":"Jaiser S","year":"2007","journal-title":"ACNR"},{"key":"bibr-ACB-10-282C3","doi-asserted-by":"publisher","DOI":"10.4065\/81.10.1371"},{"key":"bibr-ACB-10-282C4","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro1008"},{"key":"bibr-ACB-10-282C5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2009.08.008"},{"key":"bibr-ACB-10-282C6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312375.79881.94"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2011.010282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2011.010282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2011.010282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:56:25Z","timestamp":1777377385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2011.010282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1258\/acb.2011.010282"],"URL":"https:\/\/doi.org\/10.1258\/acb.2011.010282","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}