{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:06:02Z","timestamp":1777435562629,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recently developed, highly sensitive cardiac troponin T (hs-cTnT) immunoassay improves the detection of acute myocardial infarction (AMI). However, this assay requires further analytical and clinical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Imprecision, linearity, limits of quantification and interferences were evaluated; hs-cTnT was compared with a conventional cardiac troponin I assay (cTnI), performed on an X-pand\n                      <jats:sup>\u00ae<\/jats:sup>\n                      HM, in a population of patients with suspected AMI. Finally, the 99th percentile cut-off point for a reference population was explored in 213 healthy control subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Imprecision analysis demonstrated coefficients of variation (CVs) below 4%, linearity showed a 0.999 coefficient of correlation, with excellent recovery (99.9%) and a limit of quantification (10%CV) was found at 9.2 ng\/L. A negative interference (&gt;20%) with haemolysis was observed when supplemental haemoglobin was above 0.25 g\/dL. Patients with suspected AMI more frequently displayed an increased hs-cTnT (83%) than an increased cTnI (55%, P &lt; 0.01). Unstable angina was present in 63% of patients with an increased hs-cTnT associated with no increase in cTnI. The 99th percentile value for our reference population was 16.9 ng\/L. In 213 healthy blood donors, hs-cTnT levels were significantly correlated with age ( P &lt; 0.0001), and were higher in men than in women ( P &lt; 0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The analytical performance of hs-cTnT complied with the international guidelines for AMI detection. Determining the degree of haemolysis in a sample is of paramount importance to the interpretation of hs-cTnT results. The 99th percentile value of our reference population was established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2011.011019","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T20:42:02Z","timestamp":1308775322000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Analytical evaluation of a high-sensitivity troponin T assay and its clinical assessment in acute coronary syndrome"],"prefix":"10.1177","volume":"48","author":[{"given":"Camille","family":"Chenevier-Gobeaux","sequence":"first","affiliation":[{"name":"Clinical Chemistry Laboratory, Cochin and H\u00f4tel-Dieu Hospitals, Assistance Publique des H\u00f4pitaux de Paris (APHP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Meune","sequence":"additional","affiliation":[{"name":"Cardiology Department, Cochin Hospital, Universit\u00e9 Paris Descartes, Assistance Publique des H\u00f4pitaux de Paris (APHP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-C\u00e9line","family":"Blanc","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, Cochin and H\u00f4tel-Dieu Hospitals, Assistance Publique des H\u00f4pitaux de Paris (APHP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Cynober","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, Cochin and H\u00f4tel-Dieu Hospitals, Assistance Publique des H\u00f4pitaux de Paris (APHP)"},{"name":"Department of Experimental, Metabolic and Clinical Biology, Faculty of Pharmacy, Paris Descartes University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Jaffray","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, Cochin and H\u00f4tel-Dieu Hospitals, Assistance Publique des H\u00f4pitaux de Paris (APHP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Clinical Chemistry and Hormonology Department, Tenon Hospital, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"key":"bibr-ACB-11-019C1","doi-asserted-by":"publisher","DOI":"10.1177\/000456320103800501"},{"key":"bibr-ACB-11-019C2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2007.007229"},{"key":"bibr-ACB-11-019C3","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2305"},{"key":"bibr-ACB-11-019C4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm355"},{"key":"bibr-ACB-11-019C5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.12.037"},{"key":"bibr-ACB-11-019C6","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.132654"},{"key":"bibr-ACB-11-019C7","first-page":"727","volume":"50","author":"Vassault A","year":"1992","journal-title":"Ann Biol Clin (Paris)"},{"key":"bibr-ACB-11-019C8","unstructured":"Roche Diagnostics\n                      \u00ae\n                      . 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