{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:23:01Z","timestamp":1778613781048,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:00:00Z","timestamp":1309392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with primary antibody deficiency often have delayed diagnosis. Very low IgE, found during investigations for allergy, may be a marker for other immunodeficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We introduced a new laboratory policy of testing cases with very low IgE levels for possible linked antibody deficiency. The data represent an audit of routine results collected over two years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Very low IgE (\u22642 IU\/mL) was identified in 85\/2622 (3.2%) routine patient samples. Two children and four adult patients were found to have one or more classes of immunoglobulin below the reference range for age. In 2\/6, the initiative of the laboratory led to a new unsuspected diagnosis of antibody immunodeficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Common variable immunodeficiency continues to be overlooked as a primary cause of lung disease in adults. Very low serum IgE should trigger appropriate investigation (immunoglobulin quantification and serum electrophoresis).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1258\/acb.2011.011052","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T20:51:54Z","timestamp":1309467114000},"page":"459-461","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Immunoglobulin E deficiency: a forgotten clue pointing to possible immunodeficiency?"],"prefix":"10.1177","volume":"48","author":[{"given":"David J","family":"Unsworth","sequence":"first","affiliation":[{"name":"Immunology and Immunogenetics, Blood Sciences Laboratory, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F","family":"Virgo","sequence":"additional","affiliation":[{"name":"Immunology and Immunogenetics, Blood Sciences Laboratory, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Lock","sequence":"additional","affiliation":[{"name":"Immunology and Immunogenetics, Blood Sciences Laboratory, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,30]]},"reference":[{"key":"bibr-ACB-11-052C1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.016204"},{"key":"bibr-ACB-11-052C2","first-page":"529","volume":"65","author":"Bj\u00f6rkander J","year":"1984","journal-title":"Eur J Resp Dis"},{"key":"bibr-ACB-11-052C3","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63188-2"},{"key":"bibr-ACB-11-052C4","first-page":"192","volume":"56","author":"Garc\u00eda POS","year":"2009","journal-title":"Rev Allerg Mex"},{"key":"bibr-ACB-11-052C5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb11952.x"},{"key":"bibr-ACB-11-052C6","first-page":"510","volume":"64","author":"Out TA","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"bibr-ACB-11-052C7","first-page":"600","volume":"51","author":"Hammarstr\u00f6m L","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"bibr-ACB-11-052C8","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(84)90001-1"},{"key":"bibr-ACB-11-052C9","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20050"},{"key":"bibr-ACB-11-052C10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80946-4"},{"key":"bibr-ACB-11-052C11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001313020501"},{"key":"bibr-ACB-11-052C12","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.4.4.263"},{"key":"bibr-ACB-11-052C13","first-page":"375","volume":"16","author":"McLaughlan P","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"bibr-ACB-11-052C14","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(72)90132-7"},{"key":"bibr-ACB-11-052C15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4049\/jimmunol.109.2.304","volume":"109","author":"Waldmann TA","year":"1972","journal-title":"J Immunol"},{"key":"bibr-ACB-11-052C16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1975.tb00494.x"},{"key":"bibr-ACB-11-052C17","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.11.1007"},{"key":"bibr-ACB-11-052C18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6672.516"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2011.011052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1258\/acb.2011.011052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1258\/acb.2011.011052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:56:29Z","timestamp":1777377389000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1258\/acb.2011.011052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,30]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1258\/acb.2011.011052"],"URL":"https:\/\/doi.org\/10.1258\/acb.2011.011052","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,30]]}}}